Qrfprl^tm1.1Smln
Targeted Allele Detail

Summary

• Symbol: Qrfprl^tm1.1Smln
• Name: pyroglutamylated RFamide peptide receptor like; targeted mutation 1.1, Simon M Luckman
• MGI ID: MGI:7788186
• Gene: Qrfprl Location: Chr6:65358278-65435134 bp, + strand Genetic Position: Chr6, 30.19 cM
• Alliance: Qrfprl^tm1.1Smln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:355747
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was flanked by loxP sites. Exon 3 was deleted via cre-mediated recombination in the germline. This deletes the fourth transmembrane domain and generates a frameshift from exon 2 to a premature stop codon in exon 4. (J:355747)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Qrfprl Mutation: 41 strains or lines available

References

• Original: J:355747 Cook C, et al., The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors. PLoS One. 2022;17(10):e0275604
• All: 1 reference(s)