Ppp2r1b^tm1.2Yxy
Targeted Allele Detail

Summary

• Symbol: Ppp2r1b^tm1.2Yxy
• Name: protein phosphatase 2, regulatory subunit A, beta; targeted mutation 1.2, Yuxin Yin
• MGI ID: MGI:7788353
• Gene: Ppp2r1b Location: Chr9:50767946-50810625 bp, + strand Genetic Position: Chr9, 27.75 cM
• Alliance: Ppp2r1b^tm1.2Yxy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308739
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J x 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the promoter and exon 1 and an FRT-flanked neomycin resistance gene and second loxP site were inserted downstream of exon 1. The neomycin resistance gene was removed via flp-mediated recombination. The promoter and exon 1 were deleted via cre-mediated recombination. (J:308739)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp2r1b Mutation: 25 strains or lines available

References

• Original: J:308739 Du M, et al., PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis. FASEB J. 2021 May;35(5):e21564
• All: 1 reference(s)