Smndc1^em2Rkbr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Smndc1^em2Rkbr
• Name: survival motor neuron domain containing 1; endonuclease-mediated mutation 2, Robert K Bradley
• MGI ID: MGI:7788965
• Gene: Smndc1 Location: Chr19:53367821-53379009 bp, - strand Genetic Position: Chr19, 47.67 cM
• Alliance: Smndc1^em2Rkbr page

Mutation origin

• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using paired guide RNAs designed to disrupt the alternatively spliced poison exon generated a deletion of the poison exon 3' splice site. (J:353843)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smndc1 Mutation: 42 strains or lines available

References

• Original: J:353843 Belleville AE, et al., An autoregulatory poison exon in Smndc1 is conserved across kingdoms and influences organism growth. PLoS Genet. 2024 Aug;20(8):e1011363
• All: 1 reference(s)