Ceacam3^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ceacam3^em1Btlr
• Name: CEA cell adhesion molecule 3; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:7790450
• Gene: Ceacam3 Location: Chr7:16884207-16898178 bp, + strand Genetic Position: Chr7, 9.15 cM, cytoband A2
• Alliance: Ceacam3^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a T to A transversion resulting in a serine to threonine substitution at amino acid 35 (p.S35T). (J:354285)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ceacam3 Mutation: 38 strains or lines available

References

• Original: J:354285 Zhong X, et al., Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2409232121
• All: 1 reference(s)