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Zfp574m1Btlr
Chemically induced Allele Detail
Summary
Symbol: Zfp574m1Btlr
Name: zinc finger protein 574; mutation 1, Bruce Beutler
MGI ID: MGI:7790451
Synonyms: glue
Gene: Zfp574  Location: Chr7:24775099-24782917 bp, + strand  Genetic Position: Chr7, 13.73 cM
Alliance: Zfp574m1Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsThis mutation, discovered in an ENU-mutagenesis screen for altered immune cell frequencies in the peripheral blood or diminished antibody responses to immunization, comprises a T to A transversion resulting in a histidine to glutamine substitution at amino acid 512 (p.H512Q). (J:354285)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zfp574 Mutation:  27 strains or lines available
References
Original:  J:354285 Zhong X, et al., Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2409232121
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory