Zfp574^em3Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfp574^em3Btlr
• Name: zinc finger protein 574; endonuclease-mediated mutation 3, Bruce Beutler
• MGI ID: MGI:7790454
• Synonyms: Zfp574^f, Zfp574^flox
• Gene: Zfp574 Location: Chr7:24775099-24782917 bp, + strand Genetic Position: Chr7, 13.73 cM
• Alliance: Zfp574^em3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 containing the entire 2703-bp coding sequence (in transcript NM_175477.5) was flanked by loxP sites via CRISPR/Cas9 technology. (J:354285)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp574 Mutation: 27 strains or lines available

References

• Original: J:354285 Zhong X, et al., Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2409232121
• All: 1 reference(s)