Eif2ak2^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Eif2ak2^em1Btlr
• Name: eukaryotic translation initiation factor 2-alpha kinase 2; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:7790457
• Synonyms: Pkr^-
• Gene: Eif2ak2 Location: Chr17:79159993-79190002 bp, - strand Genetic Position: Chr17, 49.56 cM, cytoband E2
• Alliance: Eif2ak2^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 2-bp deletion in exon 2 resulting in a frameshift mutation that leads to a truncated protein starting at amino acid 53. (J:354285)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif2ak2 Mutation: 41 strains or lines available

References

• Original: J:354285 Zhong X, et al., Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2409232121
• All: 1 reference(s)