Plod2^tm1.1Krako
Targeted Allele Detail

Summary

• Symbol: Plod2^tm1.1Krako
• Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2; targeted mutation 1.1, Deborah Krakow
• MGI ID: MGI:7798735
• Synonyms: Plod2^fs
• Gene: Plod2 Location: Chr9:92424276-92490481 bp, + strand Genetic Position: Chr9, 48.4 cM
• Alliance: Plod2^tm1.1Krako page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:358139
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: The targeting construct introduced an FRT-flanked neomycin resistance cassette with a 5' loxP site upstream of exon 13, a frameshift mutation into exon 13a, and a second loxP site downstream of exon 14. Flp-mediated recombination removed the selection cassette. This models a variant identified in two unrelated individuals with Bruck syndrome. (J:358139)

Disease models

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plod2 Mutation: 46 strains or lines available

References

• Original: J:358139 Kot A, et al., Loss of the long form of Plod2 phenocopies contractures of Bruck syndrome-osteogenesis imperfecta. J Bone Miner Res. 2024 Sep 2;39(9):1240-1252
• All: 1 reference(s)