H3f4^em1Aha
Endonuclease-mediated Allele Detail

Summary

• Symbol: H3f4^em1Aha
• Name: H3.4 histone, cluster member; endonuclease-mediated mutation 1, Akihiro Harada
• MGI ID: MGI:7852264
• Synonyms: H3t^delta
• Gene: H3f4 Location: Chr11:58852537-58853099 bp, + strand Genetic Position: Chr11, 36.39 cM
• Alliance: H3f4^em1Aha page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted the sequence encoding the testis-specific histone H3 variant gene (H3t). Quantitative RT-PCR analysis demonstrated absence of expression in the testes of adult homozygous male mice. (J:360728)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H3f4 Mutation: 0 strains or lines available

References

• Original: J:360728 Wu Q, et al., Defects in the H3t Gene Cause an Increase in Leydig Cells With Impaired Spermatogenesis in Mice. Genes Cells. 2025;30(1):e13182
• All: 1 reference(s)