Rr596^tm1.1Low
Targeted Allele Detail

Summary

• Symbol: Rr596^tm1.1Low
• Name: regulatory region 596; targeted mutation 1.1, Malcolm J Low
• MGI ID: MGI:7853984
• Synonyms: delta1delta2, Pomc^{deltanPE1.deltanPE2}
• Gene: Rr596 Location: unknown Genetic Position: Chr12, Syntenic
• Alliance: Rr596^tm1.1Low page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224010
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Hypothalamic neuron-specific Pomc enhancers nPE1 and nPE2, located upstream of Pomc, were deleted (579 bp, 172 bp) and a loxP site flanked neomycin resistance gene cassette was inserted upstream of the nPE1 location. The neo cassette was removed through subsequent Cre-mediated recombination. (J:224010)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr596 Mutation: 0 strains or lines available

References

• Original: J:224010 Lam DD, et al., Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold. PLoS Genet. 2015 Feb;11(2):e1004935
• All: 2 reference(s)