Fdx1^tm1Xch
Targeted Allele Detail

Summary

• Symbol: Fdx1^tm1Xch
• Name: ferredoxin 1; targeted mutation 1, Xinbin Chen
• MGI ID: MGI:7855429
• Gene: Fdx1 Location: Chr9:51854606-51874856 bp, - strand Genetic Position: Chr9, 28.62 cM, cytoband B
• Alliance: Fdx1^tm1Xch page
• IMPC: Fdx1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345826
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: A construct containing an FRT site, En2-splice acceptor sequence -poly A cassette, loxP site, neo-polyA cassette, FRT site and loxP site was inserted upstream of exon 2 and a third loxP site was inserted downstream of exon 2 via homologous recombination. (J:345826)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fdx1^tm1Xch

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fdx1 Mutation: 16 strains or lines available

References

• Original: J:345826 Mohibi S, et al., Ferredoxin 1 is essential for embryonic development and lipid homeostasis. Elife. 2024 Jan 22;13
• All: 1 reference(s)