Hoxb8^em1(cre)Mrc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hoxb8^em1(cre)Mrc
• Name: homeobox B8; endonuclease-mediated mutation 1, Mario R Capecchi
• MGI ID: MGI:7855742
• Synonyms: Hoxb8^mut-IRES-Cre
• Gene: Hoxb8 Location: Chr11:96172731-96176141 bp, + strand Genetic Position: Chr11, 59.82 cM
• Alliance: Hoxb8^em1(cre)Mrc page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s), Recombinase)
• Mutation: Insertion
• Hoxb8^em1(cre)Mrc expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hoxb8 (MGI:96189)

• Mutation details: These mice were generated from Hoxb8^{tm2.1(cre)Mrc} using CRISPR/Cas9 genome editing technology to replace the sequences encoding the wild-type homeodomain DNA-binding site of Hoxb8 (I192-WFQNR198R) with the low DNA-affinity sequence AEFAAAA. (J:281069)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxb8 (mouse) Summary of all recombinase alleles driven by Hoxb8. Alliance mouse Hoxb8 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb8 Mutation: 8 strains or lines available

References

• Original: J:281069 Trankner D, et al., A Microglia Sublineage Protects from Sex-Linked Anxiety Symptoms and Obsessive Compulsion. Cell Rep. 2019 Oct 22;29(4):791-799.e3
• All: 1 reference(s)