Sptlc3^em1Cowl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sptlc3^em1Cowl
• Name: serine palmitoyltransferase, long chain base subunit 3; endonuclease-mediated mutation 1, L Ashley Cowart
• MGI ID: MGI:7858938
• Gene: Sptlc3 Location: Chr2:139335833-139478981 bp, + strand Genetic Position: Chr2, 68.52 cM
• Alliance: Sptlc3^em1Cowl page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/cas9 mediated recombination using guide RNAs inserted loxP sites around exon 8. (J:361357)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sptlc3 Mutation: 30 strains or lines available

References

• Original: J:361357 Montefusco D, et al., SPTLC3 regulates plasma membrane sphingolipid composition to facilitate hepatic gluconeogenesis. Cell Rep. 2024 Dec 24;43(12):115054
• All: 1 reference(s)