Ak6^tm1.1Zhexf
Targeted Allele Detail

Summary

• Symbol: Ak6^tm1.1Zhexf
• Name: adenylate kinase 6; targeted mutation 1.1, Xiaofeng Zheng
• MGI ID: MGI:7858964
• Gene: Ak6 Location: Chr13:100787851-100802923 bp, + strand Genetic Position: Chr13, Syntenic
• Alliance: Ak6^tm1.1Zhexf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241160
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was introduced in intron 2 and an FRT flanked neo cassette and loxP site were inserted in intron 4 via homologous recombination. Cre-mediated recombination removed exons 3 and 4 and the neo cassette. (J:241160)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ak6 Mutation: 9 strains or lines available

References

• Original: J:241160 Bai D, et al., The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth. Nat Commun. 2016 Aug 01;7:12310
• All: 2 reference(s)