Dynlt2b^em1Ktmr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dynlt2b^em1Ktmr
• Name: dynein light chain Tctex-type 2B; endonuclease-mediated mutation 1, Kentaro Tanemura
• MGI ID: MGI:7859519
• Gene: Dynlt2b Location: Chr16:32238520-32247917 bp, + strand Genetic Position: Chr16, 22.69 cM, cytoband B2
• Alliance: Dynlt2b^em1Ktmr page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs created a 4696 bp deletion including all of exons 2 and 3. Western blot analysis confirmed the loss of expression in testes from homozygous mice. (J:361529)
• Inheritance: Not Specified

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dynlt2b Mutation: 18 strains or lines available

References

• Original: J:361529 Harima R, et al., TCTEX1D2 is essential for sperm flagellum formation in mice. Sci Rep. 2025 Jan 18;15(1):2413
• All: 1 reference(s)