Col1a1^em1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Col1a1^em1Nju
• Name: collagen, type I, alpha 1; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:7863770
• Synonyms: col1a1^-365
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^em1Nju page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1029 bp deletion encompassing exons 2 to 5, resulting in a frameshift at the 26th amino acid and a stop codon at the 36th amino acid. (J:358220)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 166 strains or lines available

References

• Original: J:358220 Liu Y, et al., A novel transgenic murine model with persistently brittle bones simulating osteogenesis imperfecta type I. Bone. 2019 Oct;127:646-655
• All: 5 reference(s)