Ogfrl1^tm1.2Itl
Targeted Allele Detail

Summary

• Symbol: Ogfrl1^tm1.2Itl
• Name: opioid growth factor receptor-like 1; targeted mutation 1.2, inGenious Targeting Laboratory
• MGI ID: MGI:7865456
• Gene: Ogfrl1 Location: Chr1:23405505-23422282 bp, - strand Genetic Position: Chr1, 9.57 cM, cytoband A5
• Alliance: Ogfrl1^tm1.2Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:361287
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP sites were inserted in intron 1 and an FRT and loxP-flanked neo cassette was inserted in intron 3 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 2 and 3. (J:361287)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ogfrl1 Mutation: 24 strains or lines available

References

• Original: J:361287 Kittaka M, et al., Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism families. JBMR Plus. 2024 Jun;8(6):ziae050
• All: 1 reference(s)