Gulp1^tm1.2Kimj
Targeted Allele Detail

Summary

• Symbol: Gulp1^tm1.2Kimj
• Name: GULP, engulfment adaptor PTB domain containing 1; targeted mutation 1.1, Jung-Eun Kim
• MGI ID: MGI:7865670
• Gene: Gulp1 Location: Chr1:44590671-44835998 bp, + strand Genetic Position: Chr1, 23.63 cM, cytoband C1
• Alliance: Gulp1^tm1.2Kimj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340688
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted in intron 2 and an FRT-flanked neo cassette and loxP site were inserted in intron 3 via homologous recombination. Recombinase-mediated recombination removed the neo cassette and exon 3. (J:340688)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gulp1 Mutation: 24 strains or lines available

References

• Original: J:340688 Kim SY, et al., Gulp1 deficiency augments bone mass in male mice by affecting osteoclasts due to elevated 17beta-estradiol levels. J Cell Physiol. 2023 May;238(5):1006-1019
• All: 1 reference(s)