Abraxas2^tm1.2Bwng
Targeted Allele Detail

Summary

• Symbol: Abraxas2^tm1.2Bwng
• Name: BRISC complex subunit; targeted mutation 1.2, Bin Wang
• MGI ID: MGI:7867252
• Synonyms: Abro1^-, Abro1^delta
• Gene: Abraxas2 Location: Chr7:132460954-132486840 bp, + strand Genetic Position: Chr7, 76.32 cM
• Alliance: Abraxas2^tm1.2Bwng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245949
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and a FRT-flanked neomycin resistance gene were inserted upstream of exon 5 and second loxP site was inserted downstream of exon 5. The neomycin resistance gene and exon 5 were removed via cre-mediated recombination. (J:245949)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abraxas2 Mutation: 25 strains or lines available

References

• Original: J:245949 Xu S, et al., Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev. 2017 Jul 15;31(14):1469-1482
• All: 3 reference(s)