Litchi^em1Jnch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Litchi^em1Jnch
• Name: long non-coding RNA in Chat intron; endonuclease-mediated mutation 1, Jun-An Chen
• MGI ID: MGI:7868147
• Synonyms: Gm2990^-, Litchi-KO
• Gene: Litchi Location: Chr14:32147516-32205622 bp, + strand Genetic Position: Chr14, 19.4 cM
• Alliance: Litchi^em1Jnch page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a deletion of exon 2. In situ hybridization confirmed that expression is depleted from the spinal cords of E12.5 homozygous mutant embryos. (J:345795)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Litchi Mutation: 0 strains or lines available

References

• Original: J:345795 Hsu HC, et al., LncRNA Litchi is a regulator for harmonizing maturity and resilient functionality in spinal motor neurons. iScience. 2024 Mar 15;27(3):109207
• All: 1 reference(s)