Pknox2^em1Lff
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pknox2^em1Lff
• Name: Pbx/knotted 1 homeobox 2; endonuclease-mediated mutation 1, Lucia F Franchini
• MGI ID: MGI:7868152
• Synonyms: Pknox2^-
• Gene: Pknox2 Location: Chr9:36802278-37058637 bp, - strand Genetic Position: Chr9, 20.7 cM
• Alliance: Pknox2^em1Lff page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 20-bp deletion in exon 1, predicting a truncated protein. Western blot analysis confirmed the absence of protein expression in the brain of homozygous mutant mice. (J:344156)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pknox2 Mutation: 140 strains or lines available

References

• Original: J:344156 Trigila AP, et al., Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea. Mol Biol Evol. 2023 Jul 5;40(7)
• All: 1 reference(s)