Tmem151b^nmf389
Chemically induced Allele Detail

Summary

• Symbol: Tmem151b^nmf389
• Name: transmembrane protein 151B; neuroscience mutagenesis facility, 389
• MGI ID: MGI:7868163
• Gene: Tmem151b Location: Chr17:45852878-45860603 bp, - strand
• Alliance: Tmem151b^nmf389 page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: This 42 nucleotide deletion results in an in-frame loss of 14 amino acids (YHERVNTHVAEAEF), but no change in transcript expression was detected (J:362012)
• Inheritance: Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tmem151b^nmf389/Tmem151b^nmf389	B6N.B6J-Tmem151b^nmf389/FrkJ
hm2	Tmem151b^nmf389/Tmem151b^nmf389	C57BL/6J-Tmem151b^nmf389/J
ht3	Tmem151b^nmf389/Tmem151b^+	B6N.B6J-Tmem151b^nmf389/FrkJ
cx4	Tmem151b^tm1b(KOMP)Wtsi/Tmem151b^nmf389	B6N.Cg-Tmem151b^tm1b(KOMP)Wtsi/Tmem151b^nmf389/Frk	EPD0479_2_H11

Phenotypes:

Affected Systems	hm1	hm2	ht3	cx4
show or hide all annotated terms
behavior/neurological	√	√	√	√
seizures	√	√
abnormal seizure response to electrical stimulation	√	√	√	√
increased kindling response	√	√		√
maximal tonic hindlimb extension seizures	√	√
tonic-clonic seizures	√	√
nervous system	√	√	√	√
seizures	√	√
abnormal seizure response to electrical stimulation	√	√	√	√
increased kindling response	√	√		√
maximal tonic hindlimb extension seizures	√	√
tonic-clonic seizures	√	√
abnormal hippocampus CA1 region morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem151b Mutation: 19 strains or lines available

References

• Original: J:78134 JAX Neuroscience Mutagenesis Facility, Heritable mouse mutants from JAX NMF ENU Mutagenesis Program. MGI Direct Data Submission. 2002
• All: 2 reference(s)