Ccdc188^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccdc188^em1Osb
• Name: coiled-coil domain containing 188; endonuclease-mediated mutation 1, Osaka University
• MGI ID: MGI:7869471
• Gene: Ccdc188 Location: Chr16:18035743-18038212 bp, + strand Genetic Position: Chr16, 11.29 cM
• Alliance: Ccdc188^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using crRNA 5'-AAAGTGGGGCCAGAGGACGC-3' and 5'-CCCCTTCTTGCGCCTCGAAG-3' targeting exon 1 and exon 8 generated a 2119-bp deletion and removed most of the coding sequence. (J:361702)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc188 Mutation: 20 strains or lines available

References

• Original: J:361702 Qiu Y, et al., Loss of CCDC188 causes male infertility with defects in the sperm head-neck connection in mice. Biol Reprod. 2025 Jan 14;112(1):169-178
• All: 1 reference(s)