Tent5d^em1Adki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tent5d^em1Adki
• Name: terminal nucleotidyltransferase 5D; endonuclease-mediated mutation 1, Andrzej Dziembowski
• MGI ID: MGI:8164234
• Gene: Tent5d Location: ChrX:106836196-106916515 bp, + strand Genetic Position: ChrX, 47.62 cM
• Alliance: Tent5d^em1Adki page

Mutation origin

• Strain of Origin: (C57BL/6JTar x CBA/WTar)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 36 bp deletion and a 6 bp insertion resulting in the deletion of ten amino acids, including D82 and D84, critical for TENT5D activity, and the insertion of two amino acids (p.76-85del, insCL). (J:360869)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tent5d Mutation: 3 strains or lines available

References

• Original: J:360869 Brouze M, et al., TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice. Nat Commun. 2024 Jun 22;15(1):5331
• All: 1 reference(s)