Ell3^em1.1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ell3^em1.1Cya
• Name: elongation factor RNA polymerase II-like 3; endonuclease-mediated mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:8169535
• Synonyms: Ell3^-
• Gene: Ell3 Location: Chr2:121269508-121273082 bp, - strand Genetic Position: Chr2, 60.39 cM
• Alliance: Ell3^em1.1Cya page

Mutation origin

• Strain of Origin: C57BL/6JCya

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting floxed exons 1 through 6. Cre-mediated recombination removed exons 1-6 in the germline. (J:361580)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ell3 Mutation: 16 strains or lines available

References

• Original: J:361580 Meng S, et al., Young LINE-1 transposon 5' UTRs marked by elongation factor ELL3 function as enhancers to regulate naive pluripotency in embryonic stem cells. Nat Cell Biol. 2023 Sep;25(9):1319-1331
• All: 1 reference(s)