Lcorl^em1Jke
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lcorl^em1Jke
• Name: ligand dependent nuclear receptor corepressor-like; endonuclease-mediated mutation 1, Joel K Elmquist
• MGI ID: MGI:8169560
• Gene: Lcorl Location: Chr5:45854523-46014957 bp, - strand Genetic Position: Chr5, 25.31 cM
• Alliance: Lcorl^em1Jke page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: In an attempt to create a floxed allele using CRISPR/Cas9 technology, spontaneous nonhomologous end joining generated a deletion of 3883-bp spanning the first two exons (exons 1A and 1B) with an insertion of a single loxP site. Quantitative PCR confirmed the absence of mRNA in the hypothalamus, liver, gastrocnemius muscle, and testis. (J:360835)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcorl Mutation: 32 strains or lines available

References

• Original: J:360835 Wyler SC, et al., LCoRL Regulates Growth and Metabolism. Endocrinology. 2024 Oct 30;165(12)
• All: 1 reference(s)