Phenotypes associated with this allele

• Allele Symbol: a^e
• Allele Name: extreme nonagouti
• Allele ID: MGI:1855939
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	a^e/a^e	(P x S)F1	MGI:3611281
ht2	a^x/a^e	B6.Cg-a^x	MGI:5142469
ht3	a^16H/a^e	involves: 101/H * C3H/HeH * P * S	MGI:4361533
cx4	a^e/a^e Tbx15^de-H/Tbx15^de-H	involves: BTBR * C3H/HeJ * C57BL/6 * P * S	MGI:3767626

Genotype
MGI:3611281

hm1

• Allelic Composition: a^e/a^e
• Genetic Background: (P x S)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:13070 )

darkened coat color ( J:13070 )

• black is more intense than homozygous non-agouti

• no yellow hairs in the ears or around nipples and perineum as found in homozygous non-agouti mice

integument

abnormal coat/hair pigmentation ( J:13070 )

darkened coat color ( J:13070 )

• black is more intense than homozygous non-agouti

• no yellow hairs in the ears or around nipples and perineum as found in homozygous non-agouti mice

Genotype
MGI:5142469

ht2

• Allelic Composition: a^x/a^e
• Genetic Background: B6.Cg-a^x

integument

abnormal coat/hair pigmentation ( J:11953 )

abnormal ventral coat pigmentation ( J:11953 )

• the belly is lighter than seen for a/a or a^e/a^e mice

pigmentation

abnormal coat/hair pigmentation ( J:11953 )

abnormal ventral coat pigmentation ( J:11953 )

• the belly is lighter than seen for a/a or a^e/a^e mice

Genotype
MGI:4361533

ht3

• Allelic Composition: a^16H/a^e
• Genetic Background: involves: 101/H * C3H/HeH * P * S

pigmentation

abnormal coat/hair pigmentation ( J:8093 )

• normal nonagouti black on back but lighter, agouti belly

• black, rather than yellow, pinna hair

integument

abnormal coat/hair pigmentation ( J:8093 )

• normal nonagouti black on back but lighter, agouti belly

• black, rather than yellow, pinna hair

Genotype
MGI:3767626

cx4

• Allelic Composition: a^e/a^e; Tbx15^de-H/Tbx15^de-H
• Genetic Background: involves: BTBR * C3H/HeJ * C57BL/6 * P * S

Dorsal skin pigmentation of Tbx15^de-H/Tbx15^de-H neonates

growth/size/body

decreased body size ( J:87455 )

pigmentation

abnormal skin pigmentation ( J:87455 )

• the extent of dorsal skin pigmentation is reduced in neonates; unlike in a^e mice where neonatal skin appears uniformly dark over the entire dorsum, in double mutants, the area of dark skin is more restricted, particularly above the limbs and resembles the pattern of dorsal eumelanin in a^t Tbx15^de-H double homozygous mutants

skeleton

abnormal skeleton morphology ( J:87455 )

• skeletal abnormalities

integument

integument phenotype ( J:87455 )

N • display no coat-color phenotype

short hair ( J:87455 )

• small but consistent reduction in hair length in both dorsum and ventrum; reduced hair is most apparent in the lateral region

abnormal skin pigmentation ( J:87455 )

• the extent of dorsal skin pigmentation is reduced in neonates; unlike in a^e mice where neonatal skin appears uniformly dark over the entire dorsum, in double mutants, the area of dark skin is more restricted, particularly above the limbs and resembles the pattern of dorsal eumelanin in a^t Tbx15^de-H double homozygous mutants