All Phenotypes a<t> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

a^t
black and tan
MGI:1855941

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	a^t/a^t	Not Specified	MGI:3789010
ht2	a^t/a^tl	involves: 101/H * C3H/HeH	MGI:5471529
cx3	a^t/a^t Tbx15^de-H/Tbx15^de-H	involves: BTBR * C3H/HeJ * C57BL/6	MGI:3046089
cx4	a^t/A As/As⁺	Not Specified	MGI:4418457
cx5	a^t/a^t As/As	Not Specified	MGI:4418719
cx6	A^w/a^t As/As⁺	Not Specified	MGI:4418722

Allelic Composition	a^t/a^t
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a^t mutation (9 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:78801 )

• some yellow pigment is found in hairs originating on or behind the ears

abnormal dorsoventral coat patterning ( J:22600 , J:78801 )

• mice have a black dorsum and yellow or cream belly; a^t is dominant to A allele on the ventrum but recessive to A on the dorsum (J:22600)

• belly of animal is white, cream, or tan (yellow) in color; hairs originating on ventrum may be frequently nonpigmented, possess yellow pigment or are predominantly yellow with black bases compared to A/A mice (J:78801)

• A^w is dominant to A and all lower alleles (J:78801)

integument

abnormal coat/hair pigmentation ( J:78801 )

• some yellow pigment is found in hairs originating on or behind the ears

abnormal dorsoventral coat patterning ( J:22600 , J:78801 )

• mice have a black dorsum and yellow or cream belly; a^t is dominant to A allele on the ventrum but recessive to A on the dorsum (J:22600)

• A^w is dominant to A and all lower alleles (J:78801)

Allelic Composition	a^t/a^tl
Genetic Background	involves: 101/H * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a^t mutation (9 available); any a mutation (463 available)
a^tl mutation (0 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:169366 )

• looks like a^tl homozygotes

integument

abnormal coat/hair pigmentation ( J:169366 )

• looks like a^tl homozygotes

Allelic Composition	a^t/a^t Tbx15^de-H/Tbx15^de-H
Genetic Background	involves: BTBR * C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a^t mutation (9 available); any a mutation (463 available)
Tbx15^de-H mutation (1 available); any Tbx15 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Pigmentation phenotype of the Tbx15^de-H/Tbx15^de-H a^e/a^e mouse

pigmentation

abnormal dorsoventral coat patterning ( J:87455 )

• the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in a^t mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier

abnormal ventral coat pigmentation ( J:87455 )

• resembles pattern of a black-and-tan (a^t) mutation

irregular coat pigmentation ( J:87455 )

• abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in a^t

craniofacial

broad nasal bridge ( J:87455 )

shortened head ( J:87455 )

• elevated skull contributes lowered ear position with pinnae projecting laterally

lowered ear position ( J:87455 )

vision/eye

ocular hypertelorism ( J:87455 )

• results in widely spaced eyes

narrow eye opening ( J:87455 )

• small palpebral fissures noted

growth/size/body

broad nasal bridge ( J:87455 )

shortened head ( J:87455 )

• elevated skull contributes lowered ear position with pinnae projecting laterally

lowered ear position ( J:87455 )

decreased body size ( J:87455 )

hearing/vestibular/ear

lowered ear position ( J:87455 )

integument

abnormal dorsoventral coat patterning ( J:87455 )

abnormal ventral coat pigmentation ( J:87455 )

• resembles pattern of a black-and-tan (a^t) mutation

irregular coat pigmentation ( J:87455 )

respiratory system

broad nasal bridge ( J:87455 )

Allelic Composition	a^t/A As/As⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
As mutation (0 available); any As mutation (0 available)
a^t mutation (9 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:5027 )

• only the agouti allele on the same chromosome as the A^s allele is affected

• the expected cream belly is not seen for this genotype; the mouse looks normal agouti

integument

abnormal coat/hair pigmentation ( J:5027 )

• only the agouti allele on the same chromosome as the A^s allele is affected

• the expected cream belly is not seen for this genotype; the mouse looks normal agouti

Allelic Composition	a^t/a^t As/As
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
As mutation (0 available); any As mutation (0 available)
a^t mutation (9 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:5027 )

• unable to distinguish from homozygous a^e mice

darkened coat color ( J:5027 )

• the entire coat is dark-agouti; a cream belly is normally found on mice that are homozygous for a^t

integument

abnormal coat/hair pigmentation ( J:5027 )

• unable to distinguish from homozygous a^e mice

darkened coat color ( J:5027 )

• the entire coat is dark-agouti; a cream belly is normally found on mice that are homozygous for a^t

Allelic Composition	A^w/a^t As/As⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
As mutation (0 available); any As mutation (0 available)
a^t mutation (9 available); any a mutation (463 available)
A^w mutation (15 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:5027 )

• this allele only affects the agouti allele present on the same chromosome

• this genotype results in normal light-bellied agouti; not the anticipated cream color from the a^t allele and seen in a mouse genotype AsA^w/As<+>a^t

integument

abnormal coat/hair pigmentation ( J:5027 )

• this allele only affects the agouti allele present on the same chromosome

• this genotype results in normal light-bellied agouti; not the anticipated cream color from the a^t allele and seen in a mouse genotype AsA^w/As<+>a^t

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