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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		ax
lethal nonagouti
MGI:1855944
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		ax/ax B6.Cg-ax MGI:5050827
hm2
 		ax/ax involves: 101/Rl * C3H/Rl MGI:5085919
ht3
 		ax/a B6.Cg-ax MGI:5085916
ht4
 		ax/ae B6.Cg-ax MGI:5142469
ht5
 		ax/a involves: 101/Rl * C3H/Rl MGI:5085915


Genotype
MGI:5050827
hm1
Allelic
Composition		 ax/ax
Genetic
Background		 B6.Cg-ax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ax mutation (0 available); any a mutation (463 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:11953 )
• histological analyses reveal abnormal embryos are first evident at E4.5
• between E7.5 and E8.5 only small disorganized clumps of tissue remain

embryo
embryonic growth retardation ( J:11953 )
• blastocysts implant and develop to varying degrees some with trophoblast giant cells and primitive endoderm layer but all growth is retarded

growth/size/body
embryonic growth retardation ( J:11953 )
• blastocysts implant and develop to varying degrees some with trophoblast giant cells and primitive endoderm layer but all growth is retarded




Genotype
MGI:5085919
hm2
Allelic
Composition		 ax/ax
Genetic
Background		 involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ax mutation (0 available); any a mutation (463 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5085916
ht3
Allelic
Composition		 ax/a
Genetic
Background		 B6.Cg-ax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
ax mutation (0 available); any a mutation (463 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal coat/hair pigmentation ( J:11953 )
• at 3-4 weeks of age, mice of this genotype have more yellow-banded agouti hair on their sides than do homozygous non-agouti mice
abnormal ventral coat pigmentation ( J:11953 )
• at 3-4 weeks of age, a paler ventrum distinguishes this genotype from homozygous non-agouti or mice

pigmentation
abnormal coat/hair pigmentation ( J:11953 )
• at 3-4 weeks of age, mice of this genotype have more yellow-banded agouti hair on their sides than do homozygous non-agouti mice
abnormal ventral coat pigmentation ( J:11953 )
• at 3-4 weeks of age, a paler ventrum distinguishes this genotype from homozygous non-agouti or mice




Genotype
MGI:5142469
ht4
Allelic
Composition		 ax/ae
Genetic
Background		 B6.Cg-ax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ae mutation (4 available); any a mutation (463 available)
ax mutation (0 available); any a mutation (463 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal ventral coat pigmentation ( J:11953 )
• the belly is lighter than seen for a/a or ae/ae mice

pigmentation
abnormal ventral coat pigmentation ( J:11953 )
• the belly is lighter than seen for a/a or ae/ae mice




Genotype
MGI:5085915
ht5
Allelic
Composition		 ax/a
Genetic
Background		 involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
ax mutation (0 available); any a mutation (463 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal ventral coat pigmentation ( J:174047 )
• the coat is slightly paler than that of a homozygous non-agouti coat

pigmentation
abnormal ventral coat pigmentation ( J:174047 )
• the coat is slightly paler than that of a homozygous non-agouti coat




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory