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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clcn1adr-mto2J
myotonia 2 Jackson
MGI:1855954
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Clcn1adr-mto2J/Clcn1adr-mto2J BALB/cByJ-Clcn1adr-mto2J MGI:3763933


Genotype
MGI:3763933
hm1
Allelic
Composition		 Clcn1adr-mto2J/Clcn1adr-mto2J
Genetic
Background		 BALB/cByJ-Clcn1adr-mto2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn1adr-mto2J mutation (2 available); any Clcn1 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
impaired muscle relaxation ( J:112061 )
• mice exhibit generalized myotonia

behavior/neurological
impaired righting response ( J:112178 )
• at 2 weeks of age mice exhibit impaired ability to right

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:112178 )
• unlike in wild-type mice, evoked endplate current decay is insensitive to tetrodotoxin




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory