All Phenotypes Tyrp1<b> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tyrp1^b
brown
MGI:1855960

Summary

56 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tyrp1^b/Tyrp1^b	B6.D2-Tyrp1^b	MGI:3773275
ht2	Tyrp1^b/Tyrp1^b-65H	involves: 101/H * C3H/HeH	MGI:5308108
ht3	Tyrp1^b-cH/Tyrp1^b	involves: 101/H * C3H/HeH * T Stock	MGI:3795458
ht4	Tyrp1^b/Tyrp1^b-13DT	involves: 101/Rl * C3H/Rl	MGI:3719228
ht5	Tyrp1^b/Tyrp1^b-13R75M	involves: 101/Rl * C3H/Rl	MGI:3719231
ht6	Tyrp1^b/Tyrp1^b-173G	involves: 101/Rl * C3H/Rl	MGI:3719233
ht7	Tyrp1^b/Tyrp1^b-1DFiOD	involves: 101/Rl * C3H/Rl	MGI:3719240
ht8	Tyrp1^b/Tyrp1^b-1ETOPc	involves: 101/Rl * C3H/Rl	MGI:3719244
ht9	Tyrp1^b/Tyrp1^b-1FBleo	involves: 101/Rl * C3H/Rl	MGI:3719249
ht10	Tyrp1^b/Tyrp1^b-1FCHLc	involves: 101/Rl * C3H/Rl	MGI:3719252
ht11	Tyrp1^b/Tyrp1^b-1MLP5	involves: 101/Rl * C3H/Rl	MGI:3719256
ht12	Tyrp1^b/Tyrp1^b-1OZ	involves: 101/Rl * C3H/Rl	MGI:3719259
ht13	Tyrp1^b/Tyrp1^b-1THO-IV	involves: 101/Rl * C3H/Rl	MGI:3719262
ht14	Tyrp1^b/Tyrp1^b-11PU	involves: 101/Rl * C3H/Rl	MGI:3719218
ht15	Tyrp1^b/Tyrp1^b-2MLP10	involves: 101/Rl * C3H/Rl	MGI:3719267
ht16	Tyrp1^b/Tyrp1^b-2MLP7.5	involves: 101/Rl * C3H/Rl	MGI:3719270
ht17	Tyrp1^b/Tyrp1^b-331K	involves: 101/Rl * C3H/Rl	MGI:3719275
ht18	Tyrp1^b/Tyrp1^b-33G	involves: 101/Rl * C3H/Rl	MGI:3719277
ht19	Tyrp1^b/Tyrp1^b-37DTD	involves: 101/Rl * C3H/Rl	MGI:3719278
ht20	Tyrp1^b/Tyrp1^b-37FrThc	involves: 101/Rl * C3H/Rl	MGI:3719281
ht21	Tyrp1^b/Tyrp1^b-37Pub	involves: 101/Rl * C3H/Rl	MGI:3719282
ht22	Tyrp1^b/Tyrp1^b-3CHLe	involves: 101/Rl * C3H/Rl	MGI:3719285
ht23	Tyrp1^b/Tyrp1^b-3MLPc	involves: 101/Rl * C3H/Rl	MGI:3719356
ht24	Tyrp1^b/Tyrp1^b-3YPSc	involves: 101/Rl * C3H/Rl	MGI:3719358
ht25	Tyrp1^b/Tyrp1^b-3YPSh	involves: 101/Rl * C3H/Rl	MGI:3719360
ht26	Tyrp1^b/Tyrp1^b-46UThc	involves: 101/Rl * C3H/Rl	MGI:3719362
ht27	Tyrp1^b/Tyrp1^b-47DThWb	involves: 101/Rl * C3H/Rl	MGI:3719364
ht28	Tyrp1^b/Tyrp1^b-49HATh	involves: 101/Rl * C3H/Rl	MGI:3719366
ht29	Tyrp1^b/Tyrp1^b-4ACRg	involves: 101/Rl * C3H/Rl	MGI:3719368
ht30	Tyrp1^b/Tyrp1^b-51DThWb	involves: 101/Rl * C3H/Rl	MGI:3719370
ht31	Tyrp1^b/Tyrp1^b-55CoS	involves: 101/Rl * C3H/Rl	MGI:3719372
ht32	Tyrp1^b/Tyrp1^b-5CHLe	involves: 101/Rl * C3H/Rl	MGI:3719374
ht33	Tyrp1^b/Tyrp1^b-5CHLo	involves: 101/Rl * C3H/Rl	MGI:3719376
ht34	Tyrp1^b/Tyrp1^b-5MLPm	involves: 101/Rl * C3H/Rl	MGI:3719378
ht35	Tyrp1^b/Tyrp1^b-5FBleb	involves: 101/Rl * C3H/Rl	MGI:3719380
ht36	Tyrp1^b/Tyrp1^b-8PUb	involves: 101/Rl * C3H/Rl	MGI:3719382
ht37	Tyrp1^b/Tyrp1^b-9Bleo	involves: 101/Rl * C3H/Rl	MGI:3719384
ht38	Tyrp1^b/Tyrp1^b-9PU	involves: 101/Rl * C3H/Rl	MGI:3719386
ht39	Tyrp1^b/Tyrp1^b-9R75VH	involves: 101/Rl * C3H/Rl	MGI:3719388
ht40	Tyrp1^B-w/Tyrp1^b	involves: 101/Rl * C3H/Rl	MGI:3771332
ht41	Tyrp1^b/Tyrp1^b-26R60L	involves: 101/Rl * C3H/Rl	MGI:3719264
ht42	Tyrp1^b/Tyrp1^b-11R30M	involves: 101/Rl * C3H/Rl	MGI:3719219
ht43	Tyrp1^b/Tyrp1^b-12PU	involves: 101/Rl * C3H/Rl	MGI:3719224
ht44	Tyrp1^b/Tyrp1^b-55H	involves: C3H/HeH	MGI:5308106
ht45	Tyrp1^b/Tyrp1^rgsc671	involves: C57BL/6JJcl * DBA/2JJcl	MGI:3806985
cx46	Gpnmb^R150X/Gpnmb^R150X Tyr^c-2J/Tyr^c-2J Tyrp1^b/Tyrp1^b	B6.Cg-Tyrp1^b Gpnmb^R150X Tyr^c-2J	MGI:3773287
cx47	Gpnmb^R150X/Gpnmb^R150X Tyrp1^b/Tyrp1^b	B6.D2-Tyrp1^b Gpnmb^R150X	MGI:3773276
cx48	a/a Mlph^ln/Mlph^ln Tyrp1^b/Tyrp1^b	C57L/J	MGI:3052536
cx49	a/a Lyst^bg/Lyst^bg Tyrp1^b/Tyrp1^b	involves: C3H/Rl * C57BL/6J	MGI:4454432
cx50	a/a Tyrp1^b/Tyrp1^b	involves: C57BL/6J	MGI:4454425
cx51	Rgsc58/Rgsc58⁺ Tyrp1^b/Tyrp1^b	involves: C57BL/6JJcl * DBA/2JJcl	MGI:3798628
cx52	Lyst^bg-slt/Lyst^bg-slt Myo5a^d/Myo5a^d Oca2^p/Oca2^p Tyrp1^b/Tyrp1^b	involves: CT/Ch * YZ57/Ch	MGI:2661267
cx53	A/? Lyst^bg/Lyst^bg Tyrp1^b/Tyrp1^b	Not Specified	MGI:2654822
cx54	a/a Tyrp1^b/Tyrp1^b wad/wad⁺	Not Specified	MGI:4818897
cx55	a/a Tyrp1^b/Tyrp1^b wad/wad	Not Specified	MGI:4818908
cx56	a/a Tyrp1^b/Tyrp1^b	Not Specified	MGI:5440939

Allelic Composition	Tyrp1^b/Tyrp1^b
Genetic Background	B6.D2-Tyrp1^b

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal iris morphology ( J:128215 )

• mutants develop iris disease that is first noticeable at 6 months of age when a population of small phagocytic clump cells began to be discernible across the iris surface

• with age, the underlying vasculature becomes obscured, and irides appear increasingly coarse and atrophic, particularly at the pupil margin where a narrow white band of underlying tissue is exposed

• with advanced age, full-thickness iris holes occur, but rarely before 2 years of age

iris atrophy ( J:128215 )

• irises are normal at 1-6 months of age, however, after 6 months of age, eyes show a gradual atrophy of the iris stroma

Allelic Composition	Tyrp1^b/Tyrp1^b-65H
Genetic Background	involves: 101/H * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-65H mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat/hair pigmentation ( J:180879 )

• brown fur

craniofacial

domed cranium ( J:180879 )

small ears ( J:180879 )

growth/size/body

small ears ( J:180879 )

decreased body size ( J:180879 )

hearing/vestibular/ear

small ears ( J:180879 )

pigmentation

abnormal coat/hair pigmentation ( J:180879 )

• brown fur

skeleton

domed cranium ( J:180879 )

Allelic Composition	Tyrp1^b-cH/Tyrp1^b
Genetic Background	involves: 101/H * C3H/HeH * T Stock

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-cH mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:44436 )

• dark brown

integument

abnormal coat/hair pigmentation ( J:44436 )

• dark brown

Allelic Composition	Tyrp1^b/Tyrp1^b-13DT
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-13DT mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-13R75M
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-13R75M mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-173G
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-173G mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1DFiOD
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1DFiOD mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1ETOPc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1ETOPc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1FBleo
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1FBleo mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1FCHLc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1FCHLc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1MLP5
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1MLP5 mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1OZ
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1OZ mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1THO-IV
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1THO-IV mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-11PU
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-11PU mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-2MLP10
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-2MLP10 mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-2MLP7.5
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-2MLP7.5 mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-331K
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-331K mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-33G
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-33G mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-37DTD
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-37DTD mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-37FrThc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-37FrThc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-37Pub
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-37Pub mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-3CHLe
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-3CHLe mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

growth/size/body

decreased body weight ( J:100221 )

• weight is 45% that of same-sexed littermates

reproductive system

reduced female fertility ( J:100221 )

reduced male fertility ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-3MLPc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-3MLPc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-3YPSc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-3YPSc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-3YPSh
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-3YPSh mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-46UThc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-46UThc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-47DThWb
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-47DThWb mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-49HATh
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-49HATh mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-4ACRg
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-4ACRg mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-51DThWb
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-51DThWb mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-55CoS
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-55CoS mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-5CHLe
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-5CHLe mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-5CHLo
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-5CHLo mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-5MLPm
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-5MLPm mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-5FBleb
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-5FBleb mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-8PUb
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-8PUb mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-9Bleo
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-9Bleo mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-9PU
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-9PU mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-9R75VH
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-9R75VH mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^B-w/Tyrp1^b
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^B-w mutation (14 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:13492 , J:18590 )

• the outer two-thirds to three-quarters of the hair is brown, and the base is white (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

decreased eye pigmentation ( J:13492 )

• eye pigment resembles that of Tyrp1^b homozygotes

vision/eye

decreased eye pigmentation ( J:13492 )

• eye pigment resembles that of Tyrp1^b homozygotes

integument

diluted coat color ( J:13492 , J:18590 )

• the outer two-thirds to three-quarters of the hair is brown, and the base is white (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

Allelic Composition	Tyrp1^b/Tyrp1^b-26R60L
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-26R60L mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-11R30M
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-11R30M mutation (2 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-12PU
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-12PU mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-55H
Genetic Background	involves: C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-55H mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat/hair pigmentation ( J:180879 )

• mice resemble Tryp1^b homozygotes

pigmentation

abnormal coat/hair pigmentation ( J:180879 )

• mice resemble Tryp1^b homozygotes

Allelic Composition	Tyrp1^b/Tyrp1^rgsc671
Genetic Background	involves: C57BL/6JJcl * DBA/2JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^rgsc671 mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:133634 )

• compound heterozygotes for these two alleles have brown fur that is darker than that of mice homozygous for the classic brown mutation, Tyrp1^b, and lighter than that of Tyrp1^rgsc671 homozygotes

integument

abnormal coat/hair pigmentation ( J:133634 )

• compound heterozygotes for these two alleles have brown fur that is darker than that of mice homozygous for the classic brown mutation, Tyrp1^b, and lighter than that of Tyrp1^rgsc671 homozygotes

Allelic Composition	Gpnmb^R150X/Gpnmb^R150X Tyr^c-2J/Tyr^c-2J Tyrp1^b/Tyrp1^b
Genetic Background	B6.Cg-Tyrp1^b Gpnmb^R150X Tyr^c-2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpnmb^R150X mutation (4 available); any Gpnmb mutation (43 available)
Tyr^c-2J mutation (26 available); any Tyr mutation (379 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Tyrosinase deficiency prevents iris disease in Gpnmb^R150X/Gpnmb^R150X Tyrp1^b/Tyrp1^b Tyr^c-2J/Tyr^c-2J mice

vision/eye

vision/eye phenotype ( J:128215 )

N	• triple mutants do not develop iris disease as seen in double Gpnmb^R150X and Tyrp1^bmice

Allelic Composition	Gpnmb^R150X/Gpnmb^R150X Tyrp1^b/Tyrp1^b
Genetic Background	B6.D2-Tyrp1^b Gpnmb^R150X

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpnmb^R150X mutation (4 available); any Gpnmb mutation (43 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gpnmb^R150X/Gpnmb^R150X Tyrp1^b/Tyrp1^b mice develop a severe iris disease

vision/eye

abnormal iris morphology ( J:128215 )

• double mutants develop iris disease that is first noticeable by 6 months of age, when all eyes show slight swelling of peripupillary tissue

• at 12, 14, and 18 months of age, increasing degree of iris atrophy is observed, that includes full-thickness iris holes, profound transillumination, pigment dispersion and frequent pigment accumulation on the lens and cornea, and changes to the dimensions of the anterior chamber

• however, mutants do not develop glaucomatus nerve damage that is seen in DBA/2J mice

abnormal iris pigmentation ( J:128215 )

• severe pigment dispersing iris disease

• timing and severity of pigment dispersing iris disease is similar to that seen in either single mutant on a DBA/2J background

iris atrophy ( J:128215 )

• atrophy is seen by 6-9 months of age

abnormal intraocular pressure ( J:128215 )

• double mutants are less susceptible to intraocular pressure elevation than DBA/2J mice

pigmentation

abnormal iris pigmentation ( J:128215 )

• severe pigment dispersing iris disease

• timing and severity of pigment dispersing iris disease is similar to that seen in either single mutant on a DBA/2J background

Allelic Composition	a/a Mlph^ln/Mlph^ln Tyrp1^b/Tyrp1^b
Genetic Background	C57L/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:5095 )

diluted coat color ( J:5095 )

• due to clumping of pigment

abnormal melanocyte morphology ( J:5095 )

• results in clumping rather than even distribution of pigment during hair development

integument

abnormal coat/hair pigmentation ( J:5095 )

diluted coat color ( J:5095 )

• due to clumping of pigment

Allelic Composition	a/a Lyst^bg/Lyst^bg Tyrp1^b/Tyrp1^b
Genetic Background	involves: C3H/Rl * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Lyst^bg mutation (6 available); any Lyst mutation (225 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal choroid melanin granule morphology ( J:5346 )

• 80% of premelanosomes in the choroid and retina fuse to form giant granules

abnormal retina melanin granule morphology ( J:5346 )

• 80% of premelanosomes in the choroid and retina fuse to form giant granules

vision/eye

abnormal choroid melanin granule morphology ( J:5346 )

• 80% of premelanosomes in the choroid and retina fuse to form giant granules

abnormal retina melanin granule morphology ( J:5346 )

• 80% of premelanosomes in the choroid and retina fuse to form giant granules

Allelic Composition	a/a Tyrp1^b/Tyrp1^b
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal melanosome morphology ( J:5346 )

• reorganization of fibrillar melanosomes into particulate melanin granules, such that 20% of granules in the choroid are particulate

Allelic Composition	Rgsc58/Rgsc58⁺ Tyrp1^b/Tyrp1^b
Genetic Background	involves: C57BL/6JJcl * DBA/2JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgsc58 mutation (1 available); any Rgsc58 mutation (1 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

white spotting ( J:133634 )

• Background Sensitivity: agouti or nonagouti brown mice heterozygous for this mutation exhibit a white band-like or spotted pattern across the dorsal lumbar region

integument

white spotting ( J:133634 )

• Background Sensitivity: agouti or nonagouti brown mice heterozygous for this mutation exhibit a white band-like or spotted pattern across the dorsal lumbar region

Allelic Composition	Lyst^bg-slt/Lyst^bg-slt Myo5a^d/Myo5a^d Oca2^p/Oca2^p Tyrp1^b/Tyrp1^b
Genetic Background	involves: CT/Ch * YZ57/Ch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyst^bg-slt mutation (0 available); any Lyst mutation (225 available)
Myo5a^d mutation (105 available); any Myo5a mutation (265 available)
Oca2^p mutation (11 available); any Oca2 mutation (70 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:83269 )

integument

diluted coat color ( J:83269 )

premature hair loss ( J:83269 )

• random thinning of the coat appeared during the third week of age

abnormal hair cycle ( J:83269 )

delayed hair regrowth ( J:83269 )

• coat thinning at three weeks of age was followed by a short lag in the second hair growth cycle

Allelic Composition	A/? Lyst^bg/Lyst^bg Tyrp1^b/Tyrp1^b
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
Lyst^bg mutation (6 available); any Lyst mutation (225 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:29744 )

• on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color

• Background Sensitivity: the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice

decreased eye pigmentation ( J:29744 )

• Background Sensitivity: on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background

vision/eye

decreased eye pigmentation ( J:29744 )

• Background Sensitivity: on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background

integument

diluted coat color ( J:29744 )

• on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color

• Background Sensitivity: the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice

Allelic Composition	a/a Tyrp1^b/Tyrp1^b wad/wad⁺
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:162146 )

• Background Sensitivity: whereas heterozygosity for this mutation has no apparent effect on the agouti (A/A) background of C3H/W, on this nonagouti brown background, the coat color of mice heterozygous for wad is obviously diluted--the shade of milk chocolate versus the dark brown of wild-type animals--with occasional, interspersed darker hairs

integument

diluted coat color ( J:162146 )

Allelic Composition	a/a Tyrp1^b/Tyrp1^b wad/wad
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:162146 )

• on this background, as on the agouti background of C3H/W, the coat color of mice homozygous for this mutation is significantly diluted, appearing pale buff with occasional, interspersed darker hairs

integument

diluted coat color ( J:162146 )

Allelic Composition	a/a Tyrp1^b/Tyrp1^b
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat/hair pigmentation ( J:12970 )

• eunmelanin is brown rather than black

pigmentation

abnormal coat/hair pigmentation ( J:12970 )

• eunmelanin is brown rather than black

abnormal eye pigmentation ( J:12970 )

• eunmelanin is brown rather than black

abnormal melanocyte morphology ( J:12970 )

• cell shape is spheroid rather than ovoid

vision/eye

abnormal eye pigmentation ( J:12970 )

• eunmelanin is brown rather than black

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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