About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tyrp1B-lt
light
MGI:1855962
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tyrp1B-lt/Tyrp1B-lt involves: C57BL/6J MGI:3805204
hm2
 		Tyrp1B-lt/Tyrp1B-lt involves: C58 MGI:3664664
hm3
 		Tyrp1B-lt/Tyrp1B-lt LT/SvEiJ MGI:3707507
hm4
 		Tyrp1B-lt/Tyrp1B-lt Not Specified MGI:3687170
ht5
 		Tyrp1B-lt/Tyrp1+ involves: C58 MGI:3664744
ht6
 		Tyrp1B-lt/Tyrp1+ Not Specified MGI:3687173
cx7
 		a/a
Myo5ad/Myo5a+
Oca2p/Oca2+
Tyrp1B-lt/Tyrp1+ 		involves: C58 * CT/Ch MGI:3795191
cx8
 		a/a
Tyrp1B-lt/Tyrp1B-lt 		Not Specified MGI:3795183
cx9
 		a/a
Tyrp1B-lt/Tyrp1+ 		Not Specified MGI:3795185
cx10
 		A/a
Tyrp1B-lt/Tyrp1B-lt 		Not Specified MGI:3795188
cx11
 		Ay/a
Tyrp1B-lt/? 		Not Specified MGI:3795189
cx12
 		Cdk5rap2an/Cdk5rap2an
Tyrp1B-lt/Tyrp1B-lt 		WBB6F1 MGI:5911801


Genotype
MGI:3805204
hm1
Allelic
Composition		 Tyrp1B-lt/Tyrp1B-lt
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased bleeding time ( J:7327 )
• bleed time of 5.7 minutes on average after tail nick is higher than the 3.8 minutes in C57BL/6J controls




Genotype
MGI:3664664
hm2
Allelic
Composition		 Tyrp1B-lt/Tyrp1B-lt
Genetic
Background		 involves: C58
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:13061 )
• hair tips are brown, the rest of the hair shaft white
• mice are distinguished from normal by 2 weeks of age
• coat color is rapidly lightened as hair lengthens
• moulting often creates a mosaic coat color pattern
• the lighter coat color is difficult to see on an agouti background

integument
diluted coat color ( J:13061 )
• hair tips are brown, the rest of the hair shaft white
• mice are distinguished from normal by 2 weeks of age
• coat color is rapidly lightened as hair lengthens
• moulting often creates a mosaic coat color pattern
• the lighter coat color is difficult to see on an agouti background




Genotype
MGI:3707507
hm3
Allelic
Composition		 Tyrp1B-lt/Tyrp1B-lt
Genetic
Background		 LT/SvEiJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Tyrp1B-lt/Tyrp1B-lt

pigmentation
abnormal iris pigmentation ( J:141035 )
• iris pigmentation is dispersed

vision/eye
abnormal iris pigmentation ( J:141035 )
• iris pigmentation is dispersed




Genotype
MGI:3687170
hm4
Allelic
Composition		 Tyrp1B-lt/Tyrp1B-lt
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal strial intermediate cell morphology ( J:16249 )
• pigmentation is abundant as clumps in older mice
abnormal endocochlear potential ( J:16249 )
• loss of endocochlear potential correlates with loss of pigment
decreased endocochlear potential ( J:16249 )
• potential is reduced to 19-59mV in 30% of two age groups: 2.5 to 4 mo and 1-2 years
• loss of potential is correlated with loss of pigment with age

pigmentation
abnormal strial intermediate cell morphology ( J:16249 )
• pigmentation is abundant as clumps in older mice
abnormal coat/hair pigmentation ( J:16249 )
• pigment is lost as mice age
diluted coat color ( J:1086 )
• base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color
• pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production

integument
abnormal coat/hair pigmentation ( J:16249 )
• pigment is lost as mice age
diluted coat color ( J:1086 )
• base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color
• pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production




Genotype
MGI:3664744
ht5
Allelic
Composition		 Tyrp1B-lt/Tyrp1+
Genetic
Background		 involves: C58
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:13061 )
• the majority of each hair from tip down is pigmented, the lower part is less pigmented appearing gray
• mice are lighter than wildtype nonagouti mice but darker than homozygotes

integument
diluted coat color ( J:13061 )
• the majority of each hair from tip down is pigmented, the lower part is less pigmented appearing gray
• mice are lighter than wildtype nonagouti mice but darker than homozygotes




Genotype
MGI:3687173
ht6
Allelic
Composition		 Tyrp1B-lt/Tyrp1+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
decreased endocochlear potential ( J:16249 )
• potential is reduced in 30% of mice as mice age
• reduction in potential is correlated with appearance of abundant pigment clumps in the stria vascularis

pigmentation
abnormal coat/hair pigmentation ( J:16249 )
• coat pigment is reduced with age

integument
abnormal coat/hair pigmentation ( J:16249 )
• coat pigment is reduced with age




Genotype
MGI:3795191
cx7
Allelic
Composition		 a/a
Myo5ad/Myo5a+
Oca2p/Oca2+
Tyrp1B-lt/Tyrp1+
Genetic
Background		 involves: C58 * CT/Ch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Myo5ad mutation (105 available); any Myo5a mutation (265 available)
Oca2p mutation (11 available); any Oca2 mutation (70 available)
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:13094 )
• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment

integument
diluted coat color ( J:13094 )
• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment




Genotype
MGI:3795183
cx8
Allelic
Composition		 a/a
Tyrp1B-lt/Tyrp1B-lt
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal dorsoventral coat patterning ( J:13094 )
• the ventral hairs are substantially less pigmented than those of the dorsum
abnormal hair follicle melanin granule morphology ( J:13094 )
• although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found
• by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes
abnormal hair shaft melanin granule morphology ( J:13094 )
• variation in the amount of pigmentation present in one hair shaft versus the next
• variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft
abnormal hair shaft melanin granule distribution ( J:13094 )
• hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions
• decreased pigmentation in the hair shafts with age

integument
abnormal dorsoventral coat patterning ( J:13094 )
• the ventral hairs are substantially less pigmented than those of the dorsum
abnormal hair follicle melanin granule morphology ( J:13094 )
• although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found
• by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes
abnormal hair shaft melanin granule morphology ( J:13094 )
• variation in the amount of pigmentation present in one hair shaft versus the next
• variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft
abnormal hair shaft melanin granule distribution ( J:13094 )
• hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions
• decreased pigmentation in the hair shafts with age




Genotype
MGI:3795185
cx9
Allelic
Composition		 a/a
Tyrp1B-lt/Tyrp1+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal dorsoventral coat patterning ( J:13094 )
• the ventral hairs are substantially less pigmented than those of the dorsum
abnormal hair shaft melanin granule morphology ( J:13094 )
• large clumps of pigment are found in hair and vibrissae, but less frequently than in homozygotes
reduced hair shaft melanin granule number ( J:13094 )
• fewer pigment granules per septum in proceeding from tip to base of the hair, but more pigment granules than in homozygotes

integument
abnormal dorsoventral coat patterning ( J:13094 )
• the ventral hairs are substantially less pigmented than those of the dorsum
abnormal hair shaft melanin granule morphology ( J:13094 )
• large clumps of pigment are found in hair and vibrissae, but less frequently than in homozygotes
reduced hair shaft melanin granule number ( J:13094 )
• fewer pigment granules per septum in proceeding from tip to base of the hair, but more pigment granules than in homozygotes




Genotype
MGI:3795188
cx10
Allelic
Composition		 A/a
Tyrp1B-lt/Tyrp1B-lt
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A mutation (19 available); any a mutation (463 available)
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:13094 )
• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft

integument
diluted coat color ( J:13094 )
• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft




Genotype
MGI:3795189
cx11
Allelic
Composition		 Ay/a
Tyrp1B-lt/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Ay mutation (12 available); any a mutation (463 available)
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:13094 )
• the light mutation does not seem to impact the yellow phenotype since the coat color of mice without the light mutation is the same yellow coat color as that found in mice carrying at least one copy of the light mutation

integument
yellow coat color ( J:13094 )
• the light mutation does not seem to impact the yellow phenotype since the coat color of mice without the light mutation is the same yellow coat color as that found in mice carrying at least one copy of the light mutation




Genotype
MGI:5911801
cx12
Allelic
Composition		 Cdk5rap2an/Cdk5rap2an
Tyrp1B-lt/Tyrp1B-lt
Genetic
Background		 WBB6F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5rap2an mutation (3 available); any Cdk5rap2 mutation (87 available)
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
impaired hematopoiesis ( J:7003 )
• the mild, erythropoietin-resistant, macrocytic anemia that results from defective mitosis in homozygous stem cells can only be resuced by bone marrow transplantation from wild-type donors if the homozygotes are first lethally irradiated

cellular
abnormal mitosis ( J:7537 )
• 5% to 15% of mitotic figures obtained from a variety of homozygous tissues have abnormal mitotic figures

growth/size/body
microcephaly ( J:160533 )
• Background Sensitivity: homozygotes show modest microcephaly on a WBB6F1 background, but more severe on a C57BL/6J congenic background

reproductive system
parturition failure ( J:753 )
• homozygous females fail to deliver pups, often dying as a result, and fail to respond normally to estrogen or relaxin

neoplasm
increased histiocytic sarcoma incidence ( J:102334 )
• on the WB/Re x C57BL/6J F1 hybrid background Hertwig anemia homozygotes have greatly increased incidence of histiocytic sarcomas, with associated myelopoiesis, compared with homozygotes on congenic WB/Re or C57BL/6J backgrounds or non-homozygous mice on the WB/Re x C57BL/6J F1 hybrid background
• average age of tumor presentation begins after 1 year of age with an overall incidence in the F1 population of 63.5%

nervous system
forebrain hypoplasia ( J:160533 )
• Background Sensitivity: shortened forebrain does not extend fully over the superior colliculus of the midbrain, but this is less severe than on the C57BL/6J congenic background

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
histiocytic and dendritic cell cancer DOID:5621 J:160533
microcephaly DOID:10907 J:160533




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory