Phenotypes associated with this allele

• Allele Symbol: Tyrp1^B-w
• Allele Name: white based brown
• Allele ID: MGI:1855963
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tyrp1^B-w/Tyrp1^B-w	involves: 101/Rl * C3H/Rl	MGI:3771334
ht2	Tyrp1^B-w/Tyrp1^+	involves: 101/Rl * C3H/Rl	MGI:3771331
ht3	Tyrp1^B-w/Tyrp1^b	involves: 101/Rl * C3H/Rl	MGI:3771332
cx4	Rag1^tm1Mom/Rag1^tm1Mom Tyrp1^B-w/Tyrp1^B-w X/Tg(Tcra,Tcrb)9Rest	involves: 101/Rl * 129S7/SvEvBrd * C3H/Rl * C57BL/6	MGI:3826833

Genotype
MGI:3771334

hm1

• Allelic Composition: Tyrp1^B-w/Tyrp1^B-w
• Genetic Background: involves: 101/Rl * C3H/Rl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:13492 , J:18590 )

• the outer two-thirds to three-quarters of the hair is brown, and the base is white the resembles that of Tyrp^1B-w/Tyrp1^b mice, except that the light base is about twice as wide (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

decreased eye pigmentation ( J:13492 )

• eye pigment resembles that of Tyrp1^b homozygotes

vision/eye

decreased eye pigmentation ( J:13492 )

• eye pigment resembles that of Tyrp1^b homozygotes

integument

diluted coat color ( J:13492 , J:18590 )

• the outer two-thirds to three-quarters of the hair is brown, and the base is white the resembles that of Tyrp^1B-w/Tyrp1^b mice, except that the light base is about twice as wide (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

Genotype
MGI:3771331

ht2

• Allelic Composition: Tyrp1^B-w/Tyrp1⁺
• Genetic Background: involves: 101/Rl * C3H/Rl

pigmentation

diluted coat color ( J:13492 , J:18590 )

• pigment reduction at base of the hair (J:13492)

• the hair is almost black except for the extreme base which is light (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

integument

diluted coat color ( J:13492 , J:18590 )

• pigment reduction at base of the hair (J:13492)

• the hair is almost black except for the extreme base which is light (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

Genotype
MGI:3771332

ht3

• Allelic Composition: Tyrp1^B-w/Tyrp1^b
• Genetic Background: involves: 101/Rl * C3H/Rl

pigmentation

diluted coat color ( J:13492 , J:18590 )

• the outer two-thirds to three-quarters of the hair is brown, and the base is white (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

decreased eye pigmentation ( J:13492 )

• eye pigment resembles that of Tyrp1^b homozygotes

vision/eye

decreased eye pigmentation ( J:13492 )

• eye pigment resembles that of Tyrp1^b homozygotes

integument

diluted coat color ( J:13492 , J:18590 )

• the outer two-thirds to three-quarters of the hair is brown, and the base is white (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

Genotype
MGI:3826833

cx4

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom; Tyrp1^B-w/Tyrp1^B-w; X/Tg(Tcra,Tcrb)9Rest
• Genetic Background: involves: 101/Rl * 129S7/SvEvBrd * C3H/Rl * C57BL/6

neoplasm

abnormal tumor susceptibility ( J:138466 )

♂ • inoculation with B16 melanoma cells results in 100% tumor take in transgenic mice; tumor growth is only minimally delayed compared to non-transgenic control mice