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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lystbg-Lac
beige Laboratory animals centre
MGI:1855971
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lystbg-Lac/Lystbg-Lac CBA/CaLac-Lystbg-Lac MGI:3784690
hm2
Lystbg-Lac/Lystbg-Lac involves: CBA/CaLac MGI:3848795


Genotype
MGI:3784690
hm1
Allelic
Composition
Lystbg-Lac/Lystbg-Lac
Genetic
Background
CBA/CaLac-Lystbg-Lac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lystbg-Lac mutation (0 available); any Lyst mutation (225 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• no evidence of NK cells is observed

immune system
• no evidence of NK cells is observed

cellular
• large granules like those associated with Chediak-Higashi Syndrome are observed

craniofacial
• pigmentation is reduced, much lighter than normal

hearing/vestibular/ear
• pigmentation is reduced, much lighter than normal

limbs/digits/tail
• pigmentation is reduced, appearing much lighter than normal

pigmentation
• pigmentation is reduced, much lighter than normal
• the coat appears grey on this background
• pigmentation is reduced, appearing much lighter than normal
• eyes are light at birth, varying from ruby to almost black in adults

vision/eye
• eyes are light at birth, varying from ruby to almost black in adults

integument
• pigmentation is reduced, much lighter than normal
• the coat appears grey on this background
• pigmentation is reduced, appearing much lighter than normal

growth/size/body
• pigmentation is reduced, much lighter than normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Chediak-Higashi syndrome DOID:2935 OMIM:214500
J:29745




Genotype
MGI:3848795
hm2
Allelic
Composition
Lystbg-Lac/Lystbg-Lac
Genetic
Background
involves: CBA/CaLac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lystbg-Lac mutation (0 available); any Lyst mutation (225 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• the ears are lighter than the expected agouti pigmentation

hearing/vestibular/ear
• the ears are lighter than the expected agouti pigmentation

limbs/digits/tail
• the tail is lighter than the expected agouti pigmentation

pigmentation
• the ears are lighter than the expected agouti pigmentation
• the coat appears grey on this agouti background
• the tail is lighter than the expected agouti pigmentation

integument
• the ears are lighter than the expected agouti pigmentation
• the coat appears grey on this agouti background
• the tail is lighter than the expected agouti pigmentation

growth/size/body
• the ears are lighter than the expected agouti pigmentation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory