All Phenotypes Lyst<bg-Lac> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lyst^bg-Lac/Lyst^bg-Lac	CBA/CaLac-Lyst^bg-Lac	MGI:3784690
hm2	Lyst^bg-Lac/Lyst^bg-Lac	involves: CBA/CaLac	MGI:3848795

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent NK T cells ( J:29745 )

• no evidence of NK cells is observed

immune system

absent NK T cells ( J:29745 )

• no evidence of NK cells is observed

cellular

abnormal lysosome morphology ( J:29745 )

• large granules like those associated with Chediak-Higashi Syndrome are observed

craniofacial

decreased ear pigmentation ( J:29745 )

• pigmentation is reduced, much lighter than normal

hearing/vestibular/ear

decreased ear pigmentation ( J:29745 )

• pigmentation is reduced, much lighter than normal

limbs/digits/tail

decreased tail pigmentation ( J:29745 )

• pigmentation is reduced, appearing much lighter than normal

pigmentation

decreased ear pigmentation ( J:29745 )

• pigmentation is reduced, much lighter than normal

diluted coat color ( J:29745 )

• the coat appears grey on this background

decreased tail pigmentation ( J:29745 )

• pigmentation is reduced, appearing much lighter than normal

abnormal eye pigmentation ( J:29745 )

• eyes are light at birth, varying from ruby to almost black in adults

decreased eye pigmentation ( J:29745 )

vision/eye

abnormal eye pigmentation ( J:29745 )

• eyes are light at birth, varying from ruby to almost black in adults

decreased eye pigmentation ( J:29745 )

integument

decreased ear pigmentation ( J:29745 )

• pigmentation is reduced, much lighter than normal

diluted coat color ( J:29745 )

• the coat appears grey on this background

decreased tail pigmentation ( J:29745 )

• pigmentation is reduced, appearing much lighter than normal

growth/size/body

decreased ear pigmentation ( J:29745 )

• pigmentation is reduced, much lighter than normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Chediak-Higashi syndrome		DOID:2935	OMIM:214500	J:29745

Allelic Composition	Lyst^bg-Lac/Lyst^bg-Lac
Genetic Background	involves: CBA/CaLac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyst^bg-Lac mutation (0 available); any Lyst mutation (225 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

decreased ear pigmentation ( J:29745 )

• the ears are lighter than the expected agouti pigmentation

hearing/vestibular/ear

decreased ear pigmentation ( J:29745 )

• the ears are lighter than the expected agouti pigmentation

limbs/digits/tail

decreased tail pigmentation ( J:29745 )

• the tail is lighter than the expected agouti pigmentation

pigmentation

decreased ear pigmentation ( J:29745 )

• the ears are lighter than the expected agouti pigmentation

diluted coat color ( J:29745 )

• the coat appears grey on this agouti background

decreased tail pigmentation ( J:29745 )

• the tail is lighter than the expected agouti pigmentation

integument

decreased ear pigmentation ( J:29745 )

• the ears are lighter than the expected agouti pigmentation

diluted coat color ( J:29745 )

• the coat appears grey on this agouti background

decreased tail pigmentation ( J:29745 )

• the tail is lighter than the expected agouti pigmentation

growth/size/body

decreased ear pigmentation ( J:29745 )

• the ears are lighter than the expected agouti pigmentation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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