Phenotypes associated with this allele

• Allele Symbol: Gdf5^bp-H
• Allele Name: brachypodism Harwell
• Allele ID: MGI:1855973
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf5^bp-H/Gdf5^bp-H	involves: PCT	MGI:5003466
hm2	Gdf5^bp-H/Gdf5^bp-H	involves: PCT stock * Swiss albino	MGI:4847654

Genotype
MGI:5003466

hm1

• Allelic Composition: Gdf5^bp-H/Gdf5^bp-H
• Genetic Background: involves: PCT

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:172114 )

• hind limb development is severely compromised compared with forelimb development

• anomalies are discernable at birth

abnormal femur morphology ( J:172114 )

• histological analysis shows growth is retarded, one third the rate of normal, until E15

• growth rate of a cultured femur is greatly retarded

short femur ( J:172114 )

• observed at birth

abnormal fibula morphology ( J:172114 )

• the cultured fibula of E13 embryos do not grow during 4 days of culture

• histological analysis shows growth of the fibula is retarded, one quarter of normal, until E16

short fibula ( J:172114 )

• observed at birth

abnormal tibia morphology ( J:172114 )

• histological analysis shows retarded growth, half the rate of normal, from E13 to E14

• growth rate of a cultured tibia approximates normal

short tibia ( J:172114 )

• observed at birth

skeleton

abnormal femur morphology ( J:172114 )

• histological analysis shows growth is retarded, one third the rate of normal, until E15

• growth rate of a cultured femur is greatly retarded

short femur ( J:172114 )

• observed at birth

abnormal fibula morphology ( J:172114 )

• histological analysis shows growth of the fibula is retarded, one quarter of normal, until E16

• the cultured fibula of E13 embryos do not grow during 4 days of culture

short fibula ( J:172114 )

• observed at birth

abnormal tibia morphology ( J:172114 )

• histological analysis shows retarded growth, half the rate of normal, from E13 to E14

• growth rate of a cultured tibia approximates normal

short tibia ( J:172114 )

• observed at birth

abnormal cartilage development ( J:172114 )

• shortened long bones are the result of retardation of growth and differentiation of cartilage cells formed from postaxial mesenchyme

abnormal endochondral bone ossification ( J:172114 )

• differentiation of the femur and fibula is retarded compared with normal development

Genotype
MGI:4847654

hm2

• Allelic Composition: Gdf5^bp-H/Gdf5^bp-H
• Genetic Background: involves: PCT stock * Swiss albino

skeleton

abnormal long bone epiphyseal plate morphology ( J:166507 )

• epiphyseal cartilage of the fibula obtained within 6 hours of birth is shorter than normal, unscuptured, and shows homogeneous distribution of chondrocytes throughout the rudiment, rather than the three distinct cellular zones of the normal control

abnormal cartilage development ( J:166507 )

• fibular cartilage obtained within 6 hours of birth shows decreased chondrocyte protein synthesis, aberrant metabolism of collagen and chondroitin sulfate, and morphological abnormalities

delayed endochondral bone ossification ( J:166507 )

• evident in fibulae assessed within 6 hours of birth