integument
pigmentation
vision/eye
Allele Symbol Allele Name Allele ID |
Tyrc albino MGI:1855976 |
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Summary |
95 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• albino with pink eyes
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• albino with pink eyes
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• albino with pink eyes
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• albino with pink eyes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are white, albino as expected
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• some, but not all mice, have eye color darker than typical of albino mice
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• some, but not all mice, have eye color darker than typical of albino mice
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• mice are white, albino as expected
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• hair pigment reduced or altered all over
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• hair pigment reduced or altered all over
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• hair pigment reduced or altered all over
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• hair pigment reduced or altered all over
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• hair pigmentation is reduced to a greater extent than that of mice homozygous for Tyrc-ch83R, but not absent as in that of Tyrc (albino) homozygotes
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• hair pigmentation is reduced to a greater extent than that of mice homozygous for Tyrc-ch83R, but not absent as in that of Tyrc (albino) homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• coats of juvenile mice are very pale buff
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• coloring is intermediate between pink of albinos and deep ruby of homozygous himalayan
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• coloring is intermediate between pink of albinos and deep ruby of homozygous himalayan
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• although indistinguishable from albino at birth coat color is intermediate between albino and homozygous himalayan at about one week of age
• with the first molt extremities darken but not as dark as seen in the homozygote
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• coats of juvenile mice are very pale buff
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the hair coats of mice with this allele combination are cream colored
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• the hair coats of mice with this allele combination are cream colored
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• mice with this allele combination have cream colored hair coats and ruby colored eyes
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• the eyes of mice with this allele combination are ruby colored
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• the eyes of mice with this allele combination are ruby colored
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• very white bellies
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• very white bellies
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• slightly off-white coat color
• ear and tail hairs are slightly sooty
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• eyes are dark but no comparison to wild-type given
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• eyes are dark but no comparison to wild-type given
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• slightly off-white coat color
• ear and tail hairs are slightly sooty
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• areas of white and wild-type agouti fur
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• areas of white and wild-type agouti fur
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• these compound heterozygotes have white fur and black eyes
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• these compound heterozygotes have white fur and black eyes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the ears of these compound heterozygous mice appear lighter gray than those of Tyrem5Ove homozygotes
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• the ears of these compound heterozygous mice appear lighter gray than those of Tyrem5Ove homozygotes
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• the ears of these compound heterozygous mice appear lighter gray than those of Tyrem5Ove homozygotes
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• the ears of these compound heterozygous mice appear lighter gray than those of Tyrem5Ove homozygotes
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• the ears of these compound heterozygous mice appear lighter gray than those of Tyrem5Ove homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the fur of these Tyr compound heterozygous mice is very light-colored
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• the fur of these Tyr compound heterozygous mice is very light-colored
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• the eyes of these mice are lightly pigmented
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• the eyes of these mice are lightly pigmented
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• affected mice are albino
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• eyes appear pink
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• eyes appear pink
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• affected mice are albino
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the coat is intermediate between the homozygote and albino
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• the coat is intermediate between the homozygote and albino
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• this mouse is albino
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• this mouse is albino
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• embryonic lethality, however time of lethality is not provided
• treatment of pregnant heterozygous females with L-Dopa, a catecholamine precursor compound, from E8.5 until birth, can rescue the embryonic lethality of homozygotes
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• adrenal epinephrine levels are almost completely absent
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• brain dopamine levels are almost completely absent
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• heart, skin, brain and adrenal norepinephrine levels are almost completely absent
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• hair follicles lack stage III and IV melanosomes
• however, stage I and II melanosomes are normal
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• hair follicles lack stage III and IV melanosomes
• however, stage I and II melanosomes are normal
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• absence of fibrillar melanosomes in the choroid and retina
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• number of granules diminishes in adults after birth
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• number of granules diminishes in adults after birth
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• absence of melanin deposition on premelanosome filaments
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• number of granules diminishes in adults after birth
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• number of granules diminishes in adults after birth
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the fur of these Tyr compound heterozygous mice on a nonagouti background appears medium gray
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• the fur of these Tyr compound heterozygous mice on a nonagouti background appears medium gray
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• on a nonagouti background, the fur of these compound Tyr heterozygotes appears lighter gray than that of mice homozygous for Tyrem2Ove
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• on a nonagouti background, the fur of these compound Tyr heterozygotes appears lighter gray than that of mice homozygous for Tyrem2Ove
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• these mice exhibit lighter ocular pigmentation than Tyrem2Ove homozygotes
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• these mice exhibit lighter ocular pigmentation than Tyrem2Ove homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the fur of these Tyr compound heterozygous mice on an agouti background appears very light brown
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• the fur of these Tyr compound heterozygous mice on an agouti background appears very light brown
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice with this compound heterozygous tyrosinase genotype on an agouti background appear light agouti.
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• mice with this compound heterozygous tyrosinase genotype on an agouti background appear light agouti.
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• these compound Tyr heterozygotes on an agouti background exhibit reduced eye pigmentation at birth.
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• these compound Tyr heterozygotes on an agouti background exhibit reduced eye pigmentation at birth.
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the fur of these mice appears medium gray
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• the fur of these mice appears medium gray
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• the eyes of these mice exhibit altered pigmentation
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• the eyes of these mice exhibit altered pigmentation
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the fur of these Tyr compound heterozygous mice on an agouti background appears lighter tan than that of Tyrem6Ove homozygotes.
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• the fur of these Tyr compound heterozygous mice on an agouti background appears lighter tan than that of Tyrem6Ove homozygotes.
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• eyes are dark with mosaic pigmentation
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• eyes are dark with mosaic pigmentation
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the fur of these compound Tyr mutant mice appears light agouti
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• the fur of these compound Tyr mutant mice appears light agouti
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the fur of these Tyr compound heterozygous mice on a nonagouti background appears dark gray
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• the fur of these Tyr compound heterozygous mice on a nonagouti background appears dark gray
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• premelanosomes form normally but melanin is not deposited on the filaments and they never mature and eventually disappear in the retina
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• on an albino background mice homozygous for the chick yellow mutation have a slightly yellow coat color, which is evident by approximately 10 days of age when the first coat comes in
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• very early signs of cataracts are found at one month of age, lens extrusion and early signs of cataracts are found at 3 months of age, and retinal degeneration and cataracts are found at 7 months of age and thereafter
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• on an albino background mice homozygous for the chick yellow mutation have a slightly yellow coat color, which is evident by approximately 10 days of age when the first coat comes in
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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