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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tyrc-p
platinum
MGI:1855981
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tyrc-p/Tyrc-p involves: AKR/J * DBA/2J MGI:3833939
hm2
 		Tyrc-p/Tyrc-p involves: C57BL/6 MGI:3794762
ht3
 		Tyrc-p/Tyrc Not Specified MGI:4366464


Genotype
MGI:3833939
hm1
Allelic
Composition		 Tyrc-p/Tyrc-p
Genetic
Background		 involves: AKR/J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-p mutation (1 available); any Tyr mutation (379 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:13442 )
• mice are a shade darker than albino
absent eye pigmentation ( J:13442 )
• eyes appear pink

vision/eye
absent eye pigmentation ( J:13442 )
• eyes appear pink

integument
abnormal coat/hair pigmentation ( J:13442 )
• mice are a shade darker than albino
shiny fur ( J:13442 )
• the coat has a lustre or sheen




Genotype
MGI:3794762
hm2
Allelic
Composition		 Tyrc-p/Tyrc-p
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-p mutation (1 available); any Tyr mutation (379 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal hair follicle melanogenesis ( J:6611 , J:13319 )
• the amount of melanin found in anagen hairbulbs is reduced by more than 20-fold compared to wild-type mice (J:6611)
• affected mice fail to produce a tyrsoinase isoform with a carboxy-terminal PEP7 epitope, which participates in a high molecular weight complex important to melanogenesis (J:13319)
diluted coat color ( J:6611 )
• mice have slight pigmentation of the coat

integument
abnormal hair follicle melanogenesis ( J:6611 , J:13319 )
• the amount of melanin found in anagen hairbulbs is reduced by more than 20-fold compared to wild-type mice (J:6611)
• affected mice fail to produce a tyrsoinase isoform with a carboxy-terminal PEP7 epitope, which participates in a high molecular weight complex important to melanogenesis (J:13319)
diluted coat color ( J:6611 )
• mice have slight pigmentation of the coat




Genotype
MGI:4366464
ht3
Allelic
Composition		 Tyrc-p/Tyrc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc mutation (80 available); any Tyr mutation (379 available)
Tyrc-p mutation (1 available); any Tyr mutation (379 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:13442 )
• the coat is intermediate between the homozygote and albino

integument
abnormal coat/hair pigmentation ( J:13442 )
• the coat is intermediate between the homozygote and albino




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory