Phenotypes associated with this allele

• Allele Symbol: Cat3^vl
• Allele Name: dominant cataract 3, vacuolated lens and microphthalmia
• Allele ID: MGI:1855998
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cat3^vl/Cat3^vl	involves: 101 * C3H	MGI:2175736
ht2	Cat3^vl/Cat3^+	involves: 101 * C3H	MGI:2175737

Genotype
MGI:2175736

hm1

• Allelic Composition: Cat3^vl/Cat3^vl
• Genetic Background: involves: 101 * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:9528 )

• significant reduction in the expected 1:3 segregation ratio, due to partial lethality of homozygotes

vision/eye

abnormal iris morphology ( J:9528 )

• dysplasia

small pupil ( J:9528 )

abnormal lens morphology ( J:9528 )

• an opaque area in the anterior part of the lens

• lens dysplasia

lens vacuoles ( J:9528 )

• small vacuoles in the anterior part of the lens

microphthalmia ( J:9528 )

Genotype
MGI:2175737

ht2

• Allelic Composition: Cat3^vl/Cat3⁺
• Genetic Background: involves: 101 * C3H

vision/eye

abnormal iris morphology ( J:9528 )

• dysplasia

small pupil ( J:9528 )

abnormal lens morphology ( J:9528 )

• lens dysplasia and vacuolization

ruptured lens capsule ( J:6686 )

• occasionally the capsule ruptures and the lens substance extends into the anterior chamber

lens vacuoles ( J:9528 )

cataract ( J:6686 , J:9528 )

• opacity consists of small and large vacuoles that fill up the whole lens (J:6686)

• manifestation is bilateral and penetrance is complete (J:6686)

microphthalmia ( J:6686 , J:9528 )

• mutant eye weighs about 50% of wild-type (J:9528)

abnormal eye physiology ( J:6686 )

• pupillary dilation by atrophin is poor