pigmentation
• cultured primary melanocytes display clustering of melanosomes but are otherwise normal
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Allele Symbol Allele Name Allele ID |
Myo5ad dilute MGI:1856004 |
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Summary |
29 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• cultured primary melanocytes display clustering of melanosomes but are otherwise normal
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
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• resembles Myo5ad homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
|
• resembles Myo5ad homozygotes
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
|
• resembles Myo5ad homozygotes
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
|
• resembles Myo5ad homozygotes
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
|
• resembles Myo5ad homozygotes
|
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
|
• resembles Myo5ad homozygotes
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
|
• resembles Myo5ad homozygotes
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
|
• resembles Myo5ad homozygotes
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
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• resembles Myo5ad homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice resemble Myo5ad homozygotes
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• mice resemble Myo5ad homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice resemble Myo5ad homozygotes
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• mice resemble Myo5ad homozygotes
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
|
• resembles Myo5ad homozygotes
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
|
• resembles Myo5ad homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the heterozygote shows the same slight dilution as mice homozygous for Myo5ad-15H
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N |
• mice with this heterozygous genotype show no abnormal behavior
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• the heterozygote shows the same slight dilution as mice homozygous for Myo5ad-15H
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• resembles Myo5ad homozygotes
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• resembles Myo5ad homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• lack eye pigment
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• ear pinna lack pigment at 3-4 days of age
• extremities light in color
• paler coat color in both juveniles and adults
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• lack eye pigment
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• paler coat color in both juveniles and adults
• ear pinna lack pigment at 3-4 days of age
• extremities light in color
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Hermansky-Pudlak syndrome 3 | DOID:0060541 |
OMIM:614072 |
J:29467 |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• on the same coat-color background, mice heterozygous for both of these coat color dilution alleles are lighter than mice homozygous wild-type for both and darker than homozygous Myo5ad animals
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• on the same coat-color background, mice heterozygous for both of these coat color dilution alleles are lighter than mice homozygous wild-type for both and darker than homozygous Myo5ad animals
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• coat color is pastel gray or silver
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• eyes are red
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• eyes are red
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• coat color is pastel gray or silver
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment
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• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• coat appeared silvery blue
• melanin pigments were nearly absent from the distal third of the hair shaft, but populate the more proximal regions as heavily as in homozygous slate mice
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N |
• eye color was black, except animals that were piebald had reddish eyes
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• coat appeared silvery blue
• melanin pigments were nearly absent from the distal third of the hair shaft, but populate the more proximal regions as heavily as in homozygous slate mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• random thinning of the coat appeared during the third week of age
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• coat thinning at three weeks of age was followed by a short lag in the second hair growth cycle
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice have clumped granules in the hair and skin
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• granules tend to clump in the choroid but not in the retina
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• granules tend to clump in the choroid but not in the retina
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• mice have clumped granules in the hair and skin
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice display none of the neurological defects observed in Myo5ad mice
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N |
• mice display a normal coat color unlike the diluted coat color normally observed in Myo5ad mice
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• the number of melanocytes is increased compared to in Myo5ad mice but is still lower than in wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• clumping of melanin pigment into large granular clumps in medullary cells reduces the amount of light absorbed producing a blue-gray cast to the coat color
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• clumping of pigment creates local increase in hair diameter
• there are occasional large masses in air spaces between the medullary discs
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• pigment clumps within medullary cells
• shape, size, color, amount and color of melanin are normal
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• clumping of melanin pigment into large granular clumps in medullary cells reduces the amount of light absorbed producing a blue-gray cast to the coat color
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• reduction in cortical pigment dulls the eye color compared with wild-type
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• fewer and thinner dendritic processes compared with wild-type mice
• melanin granules concentrated in the center of cells
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• pigment clumps within medullary cells
• shape, size, color, amount and color of melanin are normal
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• reduction in cortical pigment dulls the eye color compared with wild-type
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice display a normal coat color unlike the diluted coat color normally observed in Myo5ad mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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