All Phenotypes Myo5a<d-l> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myo5a^d-l
dilute lethal
MGI:1856005

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo5a^d-l/Myo5a^d-l	involves: C57BL	MGI:3813263
ht2	Myo5a^d-90H/Myo5a^d-l	involves: 101/H * C3H/HeH * C57BL/Gr	MGI:5301940
ht3	Myo5a^d-93H/Myo5a^d-l	involves: 101/H * C3H/HeH * C57BL/Gr	MGI:5301941
cx4	Myo5a^d-l/d-100H	involves: C3H/HeH * C57BL/Gr	MGI:5311912

Allelic Composition	Myo5a^d-l/Myo5a^d-l
Genetic Background	involves: C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5a^d-l mutation (2 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired righting response ( J:12978 )

opisthotonus ( J:12978 )

• arching is very extreme

impaired balance ( J:12978 )

• hardly able to walk by 12 days of age

• moves on its side and in circles trying to stand

impaired limb coordination ( J:12978 )

clonic seizures ( J:12978 )

• 9 day old mutants show slight convulsive limb movements

• by 12 days of age convulsions are marked with fore-limbs thrashing

• by 15 days of age convulsions are triggered when mouse is disturbed, overbalances and falls and occur while mouse regains upright posture

muscle

opisthotonus ( J:12978 )

• arching is very extreme

nervous system

clonic seizures ( J:12978 )

• 9 day old mutants show slight convulsive limb movements

• by 12 days of age convulsions are marked with fore-limbs thrashing

• by 15 days of age convulsions are triggered when mouse is disturbed, overbalances and falls and occur while mouse regains upright posture

pigmentation

diluted coat color ( J:12978 )

integument

diluted coat color ( J:12978 )

Allelic Composition	Myo5a^d-90H/Myo5a^d-l
Genetic Background	involves: 101/H * C3H/HeH * C57BL/Gr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5a^d-90H mutation (0 available); any Myo5a mutation (265 available)
Myo5a^d-l mutation (2 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

opisthotonus ( J:179353 )

muscle

opisthotonus ( J:179353 )

Allelic Composition	Myo5a^d-93H/Myo5a^d-l
Genetic Background	involves: 101/H * C3H/HeH * C57BL/Gr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5a^d-93H mutation (0 available); any Myo5a mutation (265 available)
Myo5a^d-l mutation (2 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

opisthotonus ( J:179353 )

muscle

opisthotonus ( J:179353 )

Allelic Composition	Myo5a^d-l/d-100H
Genetic Background	involves: C3H/HeH * C57BL/Gr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
d-100H mutation (0 available); any d-100H mutation (0 available)
Myo5a^d-l mutation (2 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal survival ( J:181531 )

• lethal

behavior/neurological

opisthotonus ( J:181531 )

muscle

opisthotonus ( J:181531 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24