Phenotypes associated with this allele

• Allele Symbol: Myo5a^d-15H
• Allele Name: dilute 15 Harwell
• Allele ID: MGI:1856007
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo5a^d-15H/Myo5a^d-15H	Not Specified	MGI:4410292
ht2	Myo5a^d/Myo5a^d-15H	Not Specified	MGI:4410295

Genotype
MGI:4410292

hm1

• Allelic Composition: Myo5a^d-15H/Myo5a^d-15H
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:13409 )

• virtually all affected mice die between 3 and 4 weeks of age; an occasional mouse will reach adult age if routinely fed wet meal

pigmentation

diluted coat color ( J:13409 )

• only slightly diluted color compared with mice homozygous for Myo5^d

behavior/neurological

behavior/neurological phenotype ( J:13409 )

N • mice develop a severe neuromuscular disorder characterized by convulsions and opisthotonus

N • abnormalities appear at about 20 days of age

opisthotonus ( J:13409 )

seizures ( J:13409 )

muscle

opisthotonus ( J:13409 )

nervous system

seizures ( J:13409 )

integument

diluted coat color ( J:13409 )

• only slightly diluted color compared with mice homozygous for Myo5^d

Genotype
MGI:4410295

ht2

• Allelic Composition: Myo5a^d/Myo5a^d-15H
• Genetic Background: Not Specified

pigmentation

diluted coat color ( J:13409 )

• the heterozygote shows the same slight dilution as mice homozygous for Myo5a^d-15H

behavior/neurological

behavior/neurological phenotype ( J:13409 )

N • mice with this heterozygous genotype show no abnormal behavior

integument

diluted coat color ( J:13409 )

• the heterozygote shows the same slight dilution as mice homozygous for Myo5a^d-15H