Phenotypes associated with this allele

• Allele Symbol: Tbx15^de-H
• Allele Name: droopy ear Harwell
• Allele ID: MGI:1856015
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbx15^de-H/Tbx15^de-H	B6EiC3 a/A-Tbx15^de-H/J	MGI:3769577
cx2	Alx1^tm1Crm/Alx1^tm1Crm Alx4^lst-J/Alx4^lst-J Tbx15^de-H/Tbx15^de-H	involves: 129S7/SvEvBrd * C3H * C57BL/6J	MGI:3769578
cx3	Alx1^tm1Crm/Alx1^tm1Crm Alx4^lst-J/Alx4^lst-J Tbx15^de-H/Tbx15^+	involves: 129S7/SvEvBrd * C3H * C57BL/6J	MGI:3769580
cx4	Alx1^tm1Crm/Alx1^tm1Crm Tbx15^de-H/Tbx15^de-H	involves: 129S7/SvEvBrd * C3H * C57BL/6JEi	MGI:3769579
cx5	a^t/a^t Tbx15^de-H/Tbx15^de-H	involves: BTBR * C3H/HeJ * C57BL/6	MGI:3046089
cx6	a^e/a^e Tbx15^de-H/Tbx15^de-H	involves: BTBR * C3H/HeJ * C57BL/6 * P * S	MGI:3767626
cx7	Gli3^Xt-J/Gli3^Xt-J Tbx15^de-H/Tbx15^de-H	involves: C3H * C57BL/6J	MGI:3769575
cx8	Gli3^Xt-J/Gli3^Xt-J Tbx15^de-H/Tbx15^+	involves: C3H * C57BL/6J	MGI:3769576

Genotype
MGI:3769577

hm1

• Allelic Composition: Tbx15^de-H/Tbx15^de-H
• Genetic Background: B6EiC3 a/A-Tbx15^de-H/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal basioccipital bone morphology ( J:101708 )

• narrow basioccipital bone

decreased cranium height ( J:101708 )

decreased cranium width ( J:101708 )

• skull is narrower

abnormal mandibular angle morphology ( J:101708 )

• short angular process

short mandible ( J:101708 )

• in the lower jaw, the dentaries are shorter, with a short angular process

abnormal pectoral girdle bone morphology ( J:101708 )

• abnormal pectoral girdle

small acromion ( J:101708 )

• the acromion is reduced at E16.5

scapular bone foramen ( J:101708 )

• 100% penetrance

small scapula ( J:101708 )

• scapula is reduced in size and is more posteriorly and ventrally positioned at E13.5

abnormal cervical atlas morphology ( J:101708 )

• ectopic cartilage, including at this stage a tiny ossification center, is present at a corresponding position in the atlas

abnormal odontoid process morphology ( J:101708 )

• the dens of axis is reduced

abnormal vertebral arch morphology ( J:101708 )

• neural arches exhibit various abnormalities, including an axis with widened arches along the anteroposterior direction

craniofacial

abnormal basioccipital bone morphology ( J:101708 )

• narrow basioccipital bone

decreased cranium height ( J:101708 )

decreased cranium width ( J:101708 )

• skull is narrower

abnormal mandibular angle morphology ( J:101708 )

• short angular process

short mandible ( J:101708 )

• in the lower jaw, the dentaries are shorter, with a short angular process

abnormal ear position ( J:101708 )

• abnormal position of the ears

hearing/vestibular/ear

abnormal ear position ( J:101708 )

• abnormal position of the ears

growth/size/body

abnormal ear position ( J:101708 )

• abnormal position of the ears

Genotype
MGI:3769578

cx2

• Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm; Alx4^lst-J/Alx4^lst-J; Tbx15^de-H/Tbx15^de-H
• Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6J

skeleton

absent clavicle ( J:101708 )

small scapula ( J:101708 )

• severe reduction of the scapular blade at E16.5; the only remnants of the scapula are the glenoid fossa, a small fraction of the acromion, and the posterior part of the blade

Genotype
MGI:3769580

cx3

• Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm; Alx4^lst-J/Alx4^lst-J; Tbx15^de-H/Tbx15⁺
• Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6J

skeleton

abnormal scapula morphology ( J:101708 )

• scapular blade is more severely malformed than in double Alx4 and Alx1 mutants

abnormal scapular spine morphology ( J:101708 )

• spine is more reduced than in double Alx4 and Alx1 mutants

Genotype
MGI:3769579

cx4

• Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm; Tbx15^de-H/Tbx15^de-H
• Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6JEi

skeleton

scapular bone foramen ( J:101708 )

• scapula foramen which is larger than in single Tbx15 homozygotes

Genotype
MGI:3046089

cx5

• Allelic Composition: a^t/a^t; Tbx15^de-H/Tbx15^de-H
• Genetic Background: involves: BTBR * C3H/HeJ * C57BL/6

Pigmentation phenotype of the Tbx15^de-H/Tbx15^de-H a^e/a^e mouse

pigmentation

abnormal dorsoventral coat patterning ( J:87455 )

• the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in a^t mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier

abnormal ventral coat pigmentation ( J:87455 )

• resembles pattern of a black-and-tan (a^t) mutation

irregular coat pigmentation ( J:87455 )

• abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in a^t

craniofacial

broad nasal bridge ( J:87455 )

shortened head ( J:87455 )

• elevated skull contributes lowered ear position with pinnae projecting laterally

lowered ear position ( J:87455 )

vision/eye

ocular hypertelorism ( J:87455 )

• results in widely spaced eyes

narrow eye opening ( J:87455 )

• small palpebral fissures noted

growth/size/body

broad nasal bridge ( J:87455 )

shortened head ( J:87455 )

• elevated skull contributes lowered ear position with pinnae projecting laterally

lowered ear position ( J:87455 )

decreased body size ( J:87455 )

hearing/vestibular/ear

lowered ear position ( J:87455 )

integument

abnormal dorsoventral coat patterning ( J:87455 )

• the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in a^t mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier

abnormal ventral coat pigmentation ( J:87455 )

• resembles pattern of a black-and-tan (a^t) mutation

irregular coat pigmentation ( J:87455 )

• abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in a^t

respiratory system

broad nasal bridge ( J:87455 )

Genotype
MGI:3767626

cx6

• Allelic Composition: a^e/a^e; Tbx15^de-H/Tbx15^de-H
• Genetic Background: involves: BTBR * C3H/HeJ * C57BL/6 * P * S

Dorsal skin pigmentation of Tbx15^de-H/Tbx15^de-H neonates

growth/size/body

decreased body size ( J:87455 )

pigmentation

abnormal skin pigmentation ( J:87455 )

• the extent of dorsal skin pigmentation is reduced in neonates; unlike in a^e mice where neonatal skin appears uniformly dark over the entire dorsum, in double mutants, the area of dark skin is more restricted, particularly above the limbs and resembles the pattern of dorsal eumelanin in a^t Tbx15^de-H double homozygous mutants

skeleton

abnormal skeleton morphology ( J:87455 )

• skeletal abnormalities

integument

integument phenotype ( J:87455 )

N • display no coat-color phenotype

short hair ( J:87455 )

• small but consistent reduction in hair length in both dorsum and ventrum; reduced hair is most apparent in the lateral region

abnormal skin pigmentation ( J:87455 )

• the extent of dorsal skin pigmentation is reduced in neonates; unlike in a^e mice where neonatal skin appears uniformly dark over the entire dorsum, in double mutants, the area of dark skin is more restricted, particularly above the limbs and resembles the pattern of dorsal eumelanin in a^t Tbx15^de-H double homozygous mutants

Genotype
MGI:3769575

cx7

• Allelic Composition: Gli3^Xt-J/Gli3^Xt-J; Tbx15^de-H/Tbx15^de-H
• Genetic Background: involves: C3H * C57BL/6J

skeleton

small acromion ( J:101708 )

• the acromion is more severely reduced than in either single mutant

small scapula ( J:101708 )

• severe reduction of the scapular blade when compared to either single mutant, lacking the posterior part of the blade

Genotype
MGI:3769576

cx8

• Allelic Composition: Gli3^Xt-J/Gli3^Xt-J; Tbx15^de-H/Tbx15⁺
• Genetic Background: involves: C3H * C57BL/6J

skeleton

abnormal scapula morphology ( J:101708 )

• scapular blade is broader

scapular bone foramen ( J:101708 )

• scapular foramen is enlarged in comparison with single Tbx15 mutants