Analysis Tools|
Allele Symbol Allele Name Allele ID |
Dstdt dystonia musculorum MGI:1856019 |
| Summary |
3 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the peripheral nervous system, there is some segmental demyelination and other abnormalities of the myelin sheaths
• transplantation experiments with sciatic nerve show that the defect resides in the Schwann cells, not in the axons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• originally some mice survive for months but successive generations exhibit lethality by 3 to 4 weeks of age
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• mice alternate between hyperextension and hyperflexion of the limbs but no paralysis is evident
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• the nervous system shows degenerative changes and progressive loss of nerve fibers in the central and peripheral branches of the sensory ganglion cells of the spinal and cranial nerves, in the central sensory pathways, and in peripheral sensory structures such as skin, Pacinian corpuscles, and muscle spindles
• in animals that survive longer there is also evidence of lower motor neuron involvement
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die by 3 to 4 weeks of age
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• in the peripheral nervous system
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• mice exhibit loss of nerve fibers with fibrosis in the peripheral and gliosis in the central nervous system
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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