Phenotypes associated with this allele

• Allele Symbol: Dst^dt-J
• Allele Name: dystonia musculorum Jackson
• Allele ID: MGI:1856021
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dst^dt-J/Dst^dt-J	B6C3Fe a/a-Dst^dt-J/J	MGI:3581043
hm2	Dst^dt-J/Dst^dt-J	C3HeB/FeJ-Dst^dt-J	MGI:3620622

Genotype
MGI:3581043

hm1

• Allelic Composition: Dst^dt-J/Dst^dt-J
• Genetic Background: B6C3Fe a/a-Dst^dt-J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased aggression ( J:106403 )

• animals are less reactive to provoked biting

abnormal postural reflex ( J:106403 )

• mutants showed significant alterations in all measures of postural reflexes other than contact righting

abnormal response to tactile stimuli ( J:106403 )

• animals are less reactive to touch (smaller escape reflex

decreased startle reflex ( J:106403 )

• animals are less reactive to auditory stimuli

tremors ( J:106403 )

• some animals display tremor while at rest and in movement

abnormal motor coordination/balance ( J:106403 )

• animals exhibit limb flexion when suspended by the tail

ataxia ( J:106403 )

• mutants are ataxic

impaired balance ( J:106403 )

• rears and grooming in mutants are usually incomplete due to loss of equilibrium

impaired coordination ( J:106403 )

• mutants fall more quickly in stationary beam tests than controls; latencies before falling increase over several days

abnormal posture ( J:106403 )

• animals exhibit folding to the trunk when suspended by the tail

positive geotaxis ( J:106403 )

• animals do not exhibit negative geotaxis and fall off an inclined grid immediately

growth/size/body

decreased body weight ( J:106403 )

• mutants have 58% lower mean bodyweights than controls

pigmentation

abnormal skin pigmentation ( J:106403 )

• animals have paler skin than controls

vision/eye

abnormal eye distance/ position ( J:106403 )

• eyes of majority of mutants are half-closed

enophthalmos ( J:106403 )

• eyes of mutants seem less prominent

integument

abnormal skin pigmentation ( J:106403 )

• animals have paler skin than controls

Genotype
MGI:3620622

hm2

• Allelic Composition: Dst^dt-J/Dst^dt-J
• Genetic Background: C3HeB/FeJ-Dst^dt-J

mortality/aging

postnatal lethality, complete penetrance ( J:24773 )

• no homozygote has lived beyond 23 day

behavior/neurological

abnormal motor coordination/balance ( J:24773 )

• animals make constant swimming motions while on their bellies

athetotic walking movements ( J:24773 )

• animals are unable to walk normally

abnormal posture ( J:24773 )

• animals are unable to stand normally