All Phenotypes Cacna2d2<du-td> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna2d2^du-td/Cacna2d2^du-td	DBA/2J-Cacna2d2^du-td	MGI:3797574
hm2	Cacna2d2^du-td/Cacna2d2^du-td	involves: DBA/2J	MGI:3797572

Allelic Composition	Cacna2d2^du-td/Cacna2d2^du-td
Genetic Background	DBA/2J-Cacna2d2^du-td

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna2d2^du-td mutation (0 available); any Cacna2d2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:13433 )

• while mice swim slowly, they are unable to hold onto a rope

lethargy ( J:13433 )

• mice exhibit slow movements

tremors ( J:13433 )

• mice lie on their backs for minutes at a time, sometimes with the mouth and feet quivering

• when standing, one foot is often raised and quivers

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:12166 )

• mice exhibit high mortality rates between 3 and 4 weeks of age

reproductive system

absent corpus luteum ( J:12166 )

reduced fertility ( J:12166 )

• mice exhibit reduced reproductivity

reduced female fertility ( J:5596 )

• in female mice

immune system

abnormal thymus involution ( J:12166 )

• mice undergo thymus involution soon after the onset of neurological symptoms

endocrine/exocrine glands

abnormal pituitary gland morphology ( J:12166 )

• pituitary glands exhibit an increase in cellular population density compared to in wild-type pituitaries

absent lactotrophs ( J:5596 )

absent corpus luteum ( J:12166 )

abnormal thymus involution ( J:12166 )

• mice undergo thymus involution soon after the onset of neurological symptoms

growth/size/body

postnatal growth retardation ( J:5596 , J:12166 )

• in female mice (J:5596)

hematopoietic system

abnormal thymus involution ( J:12166 )

• mice undergo thymus involution soon after the onset of neurological symptoms

nervous system

abnormal pituitary gland morphology ( J:12166 )

• pituitary glands exhibit an increase in cellular population density compared to in wild-type pituitaries

absent lactotrophs ( J:5596 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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