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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mc1re
recessive yellow
MGI:1856028
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mc1re/Mc1re C57BL/6J-Mc1re/J MGI:3686787
hm2
 		Mc1re/Mc1re involves: C57BL/6 MGI:3689211
hm3
 		Mc1re/Mc1re involves: C57BL/6Ha MGI:3805936
ht4
 		Mc1rtaw/Mc1re involves: M. m. molossinus * C57BL/6J MGI:3689992
cx5
 		a/a
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/? 		involves: 129S6/SvEvTac * C57BL/6Ha MGI:3805943
cx6
 		a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/? 		involves: 129S6/SvEvTac * C57BL/6Ha MGI:3805942
cx7
 		Mc1re/Mc1re
Xpctm1Brd/Xpctm1Brd
Tg(KRT14-Kitl)1Takk/0 		involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:3686788
cx8
 		Ay-Jkn/A
Mc1re/Mc1re 		involves: C57BL/6Ha * C57BL/6N MGI:3805938
cx9
 		Ay-Jkn/A
Mc1re/Mc1re
Tg(MC1R)1Jkn/0 		involves: C57BL/6Ha * C57BL/6N MGI:3805939
cx10
 		Adamts20bt/Adamts20bt
Mc1re/Mc1re 		involves: C57BL/6Ha * DBA/2J MGI:3689348
cx11
 		Mc1re/Mc1re
Pepddal/Pepddal 		involves: C57BL/6J * CBA/J MGI:5605682
cx12
 		Mc1re/Mc1re
Tg(KRT14-Kitl)1Takk/0 		involves: C57BL/6 * SJL MGI:3686789
cx13
 		Mc1re/Mc1re
Mlphln/Mlphln 		Not Specified MGI:3689357
cx14
 		Ednrbs/Ednrbs
Mc1re/Mc1re 		Not Specified MGI:3689347


Genotype
MGI:3686787
hm1
Allelic
Composition		 Mc1re/Mc1re
Genetic
Background		 C57BL/6J-Mc1re/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1re mutation (4 available); any Mc1r mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal skin pigmentation ( J:112959 )
• mice show no UV-induced detectable pigmentation changes, while wild-type ears show grossly and microscopically detectable hyperpigmentation
abnormal melanogenesis ( J:112959 )
• in mutants, no measurable UV-induced melanization is observed; forskolin application to the skin induces significant skin darkening

cellular
abnormal keratinocyte apoptosis ( J:112959 )
• forskolin pre-treatment produces UV protection similar to wild-type (black skinned) mice while untreated mutants are very UV-sensitive; untreated mice show formation of sunburn cells 24 hours after UV exposure

integument
abnormal keratinocyte apoptosis ( J:112959 )
• forskolin pre-treatment produces UV protection similar to wild-type (black skinned) mice while untreated mutants are very UV-sensitive; untreated mice show formation of sunburn cells 24 hours after UV exposure
abnormal skin pigmentation ( J:112959 )
• mice show no UV-induced detectable pigmentation changes, while wild-type ears show grossly and microscopically detectable hyperpigmentation




Genotype
MGI:3689211
hm2
Allelic
Composition		 Mc1re/Mc1re
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1re mutation (4 available); any Mc1r mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal touch/ nociception ( J:112815 )
• mutant females and males display reduced pain sensitivity
abnormal pain threshold ( J:112815 )
• males display significantly higher latencies than females for the 49 degree water tail withdrawal test
analgesia ( J:112815 )
• 6-10 week old females and males display increased analgesic responsiveness to morphine-6-glucuronide when challenged with thermal nociception




Genotype
MGI:3805936
hm3
Allelic
Composition		 Mc1re/Mc1re
Genetic
Background		 involves: C57BL/6Ha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1re mutation (4 available); any Mc1r mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:5110 , J:5620 , J:129904 )
• the clear yellow color accentuates the normal black eye color (J:5110)
• the entire length of the hair is yellow in adults; prior to weaning, homozygotes exhibit some dorsally concentrated umbrous sootiness but acquire an overall yellow coat with sucessive molts (J:5110)
• young mice have some eumelanin deposited in the hair tips, but adults have hairs predominantly pigmented with pheomelanin (J:5620)
• mice have a yellow coat (J:129904)
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is much higher (2.73) than in agouti controls (0.19)
abnormal hair follicle melanogenesis ( J:5563 )
• neural tube-skin recombination grafting technique demonstrates that phaeomelanin (yellow coat color) is controlled by melanocyte genotype; not skin genotype

integument
yellow coat color ( J:5110 , J:5620 , J:129904 )
• the clear yellow color accentuates the normal black eye color (J:5110)
• the entire length of the hair is yellow in adults; prior to weaning, homozygotes exhibit some dorsally concentrated umbrous sootiness but acquire an overall yellow coat with sucessive molts (J:5110)
• young mice have some eumelanin deposited in the hair tips, but adults have hairs predominantly pigmented with pheomelanin (J:5620)
• mice have a yellow coat (J:129904)
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is much higher (2.73) than in agouti controls (0.19)
abnormal hair follicle melanogenesis ( J:5563 )
• neural tube-skin recombination grafting technique demonstrates that phaeomelanin (yellow coat color) is controlled by melanocyte genotype; not skin genotype




Genotype
MGI:3689992
ht4
Allelic
Composition		 Mc1rtaw/Mc1re
Genetic
Background		 involves: M. m. molossinus * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1re mutation (4 available); any Mc1r mutation (43 available)
Mc1rtaw mutation (0 available); any Mc1r mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:55617 )
• the yellow coat color of the F1 demonstrates allelism; however, hair of the F1 contains black pigment characteristic of homozygous Mc1rtaw mice, demonstrating that Mc1rtaw is dominant to Mc1re

integument
yellow coat color ( J:55617 )
• the yellow coat color of the F1 demonstrates allelism; however, hair of the F1 contains black pigment characteristic of homozygous Mc1rtaw mice, demonstrating that Mc1rtaw is dominant to Mc1re




Genotype
MGI:3805943
cx5
Allelic
Composition		 a/a
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6Ha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (467 available)
Mc1re mutation (4 available); any Mc1r mutation (43 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (18 available)
Tg(MC1R)1Jkn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (1.74) than in controls (0.20)

integument
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (1.74) than in controls (0.20)




Genotype
MGI:3805942
cx6
Allelic
Composition		 a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6Ha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (467 available)
A mutation (19 available); any a mutation (467 available)
Mc1re mutation (4 available); any Mc1r mutation (43 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (18 available)
Tg(MC1R)1Jkn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)

integument
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)




Genotype
MGI:3686788
cx7
Allelic
Composition		 Mc1re/Mc1re
Xpctm1Brd/Xpctm1Brd
Tg(KRT14-Kitl)1Takk/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1re mutation (4 available); any Mc1r mutation (43 available)
Tg(KRT14-Kitl)1Takk mutation (1 available)
Xpctm1Brd mutation (1 available); any Xpc mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
weight loss ( J:112959 )
• vehicle-treated mutants show weight loss, indicative of failure to thrive, compared to forskolin-treated animals

neoplasm
increased tumor incidence ( J:112959 )
• vehicle-treated mutant controls develop tumors more rapidly (11 tumors ~4 weeks after 20 weeks of UV-B exposure) compared to forskolin-treated mice (6 tumors, onset ~25 weeks)
• other types of tumors are found in vehicle-treated mice (3/11); 2/9 mice develop multiple tumors
increased squamous cell carcinoma incidence ( J:112959 )
• tumors in vehicle-treated mutants are mainly this type (6/11) while forskolin-treated mice develop only this type

integument
thick epidermis ( J:112959 )
• vehicle-treated mutants show significant sun damage after 20 weeks of UV-B exposure including profound epidermal thickening while forskoling treatment prevented damage
skin lesions ( J:112959 )
• vehicle-treated mutants show evidence of sun damage like scarring after 20 weeks of UV-B exposure while forskolin treatment prevented damage




Genotype
MGI:3805938
cx8
Allelic
Composition		 Ay-Jkn/A
Mc1re/Mc1re
Genetic
Background		 involves: C57BL/6Ha * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (467 available)
Ay-Jkn mutation (0 available); any a mutation (467 available)
Mc1re mutation (4 available); any Mc1r mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jknheterozygotes

integument
yellow coat color ( J:129904 )
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jknheterozygotes




Genotype
MGI:3805939
cx9
Allelic
Composition		 Ay-Jkn/A
Mc1re/Mc1re
Tg(MC1R)1Jkn/0
Genetic
Background		 involves: C57BL/6Ha * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (467 available)
Ay-Jkn mutation (0 available); any a mutation (467 available)
Mc1re mutation (4 available); any Mc1r mutation (43 available)
Tg(MC1R)1Jkn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jkn heterozygotes

integument
yellow coat color ( J:129904 )
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jkn heterozygotes




Genotype
MGI:3689348
cx10
Allelic
Composition		 Adamts20bt/Adamts20bt
Mc1re/Mc1re
Genetic
Background		 involves: C57BL/6Ha * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt mutation (1 available); any Adamts20 mutation (93 available)
Mc1re mutation (4 available); any Mc1r mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belted ( J:5110 )
• amount of "belting" is decreased in mice of this allelic combination although genetic background effects are not considered

integument
belted ( J:5110 )
• amount of "belting" is decreased in mice of this allelic combination although genetic background effects are not considered




Genotype
MGI:5605682
cx11
Allelic
Composition		 Mc1re/Mc1re
Pepddal/Pepddal
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1re mutation (4 available); any Mc1r mutation (43 available)
Pepddal mutation (1 available); any Pepd mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
yellow coat color ( J:143333 )
• double homozygotes have a clear yellow coat color indistingishable from e homozygotes

pigmentation
yellow coat color ( J:143333 )
• double homozygotes have a clear yellow coat color indistingishable from e homozygotes

growth/size/body
decreased body size ( J:143333 )
• some, but not all, are smaller than normal at wean age




Genotype
MGI:3686789
cx12
Allelic
Composition		 Mc1re/Mc1re
Tg(KRT14-Kitl)1Takk/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1re mutation (4 available); any Mc1r mutation (43 available)
Tg(KRT14-Kitl)1Takk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal melanogenesis ( J:112959 )
• in mutants, no measurable UV-induced melanization is observed; forskolin application to the skin induces significant skin darkening




Genotype
MGI:3689357
cx13
Allelic
Composition		 Mc1re/Mc1re
Mlphln/Mlphln
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1re mutation (4 available); any Mc1r mutation (43 available)
Mlphln mutation (6 available); any Mlph mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:5110 )
• homozygosity for the leaden allele masks the yellow coat color of homozygous mutant Mc1re mice

integument
diluted coat color ( J:5110 )
• homozygosity for the leaden allele masks the yellow coat color of homozygous mutant Mc1re mice




Genotype
MGI:3689347
cx14
Allelic
Composition		 Ednrbs/Ednrbs
Mc1re/Mc1re
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs mutation (19 available); any Ednrb mutation (103 available)
Mc1re mutation (4 available); any Mc1r mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
white spotting ( J:5110 )
• amount of white spotting decreased, although genetic background modifiers are not considered

integument
white spotting ( J:5110 )
• amount of white spotting decreased, although genetic background modifiers are not considered




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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory