mortality/aging
• the largest loss of homozygotes occurs before birth
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Allele Symbol Allele Name Allele ID |
Frla furloss a MGI:1856032 |
Summary |
2 genotypes |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the largest loss of homozygotes occurs before birth
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• affected mice are normal in size until about 16 days of age when they appear smaller than normal littermates
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• weanlings weigh 8.8 percent less than wild-type littermates
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• random hair loss in patches occurs on the forehead, then back and abdomen
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• after the final shedding cycle there is increasing hair loss until 12-14 weeks of age when affected mice are completely bare except for the muzzle
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• typical at 40 days of age
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• Background Sensitivity: on this background affected mice have a slight coat striation compared with normal littermates by 7 days of age; on BALB/c (N7) this feature is distinguishable by 10 days of age
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• patchy loss of the first coat is followed by regrowth during days 16-20, followed by second patchy shedding one week later
• final shedding cycle begins soon after 40 days of age, first on the forehead and spreads over the back and abdomen
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• Background Sensitivity: on this background by 7 days of age wrinkled skin differentiates affected mice from normal littermates; on BALB/c (N7) affected mice are distinguishable from normal littermates by 10 days of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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