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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Frla
furloss a
MGI:1856032
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Frla/Frla Not Specified MGI:4361489
ht2
Frla/Frl+ Not Specified MGI:4360640


Genotype
MGI:4361489
hm1
Allelic
Composition
Frla/Frla
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frla mutation (2 available); any Frl mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the largest loss of homozygotes occurs before birth




Genotype
MGI:4360640
ht2
Allelic
Composition
Frla/Frl+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frla mutation (2 available); any Frl mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• affected mice are normal in size until about 16 days of age when they appear smaller than normal littermates
• weanlings weigh 8.8 percent less than wild-type littermates

integument
• random hair loss in patches occurs on the forehead, then back and abdomen
• after the final shedding cycle there is increasing hair loss until 12-14 weeks of age when affected mice are completely bare except for the muzzle
• typical at 40 days of age
• Background Sensitivity: on this background affected mice have a slight coat striation compared with normal littermates by 7 days of age; on BALB/c (N7) this feature is distinguishable by 10 days of age
• patchy loss of the first coat is followed by regrowth during days 16-20, followed by second patchy shedding one week later
• final shedding cycle begins soon after 40 days of age, first on the forehead and spreads over the back and abdomen
• Background Sensitivity: on this background by 7 days of age wrinkled skin differentiates affected mice from normal littermates; on BALB/c (N7) affected mice are distinguishable from normal littermates by 10 days of age





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory