Phenotypes associated with this allele

• Allele Symbol: Sgk3^fz
• Allele Name: fuzzy
• Allele ID: MGI:1856038
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sgk3^fz/Sgk3^fz	CFW stock	MGI:3589947
cx2	Mlph^ln/Mlph^ln Sgk3^fz/Sgk3^fz	C57BL/6J-Sgk3^fz Mlph^ln	MGI:3804905

Genotype
MGI:3589947

hm1

• Allelic Composition: Sgk3^fz/Sgk3^fz
• Genetic Background: CFW stock

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal coat/ hair morphology ( J:90 )

• noticed in new truncal coat by 6 days of age

• all hair types are present but are thin and curly

abnormal hair texture ( J:90 )

• coat is uneven

waved hair ( J:90 )

• coat is slightly delayed and uneven

• with new generations of hair, coat is thicker and curlier

abnormal hair follicle morphology ( J:15247 )

• follicles fail to lengthen

abnormal hair follicle dermal papilla morphology ( J:15247 )

• cell size and arrangement is abnormal

• is the result of an abnormal interaction of dermis and epidermis

small hair follicle bulb ( J:15247 )

• the bulb remains small and rounded

wavy vibrissae ( J:90 )

• whiskers are thin and slightly waved

• noticed between birth and 2 days

early exit from anagen phase ( J:15247 )

• period of active hair growth is reduced

abnormal epidermal layer morphology ( J:5551 )

• dermal-epidermal exchange experiments show mutant epidermis is unable to produce normal hair in response to dermal signals

Genotype
MGI:3804905

cx2

• Allelic Composition: Mlph^ln/Mlph^ln; Sgk3^fz/Sgk3^fz
• Genetic Background: C57BL/6J-Sgk3^fz Mlph^ln

homeostasis/metabolism

decreased bleeding time ( J:7327 )

• bleed time of 0.7 minutes after tail nick is significantly less than the 3.8 minutes in C57BL/6J controls