Phenotypes associated with this allele

• Allele Symbol: Grid2^ho-Jwg
• Allele Name: hotfoot, Jon W Gordon
• Allele ID: MGI:1856053
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grid2^ho-Jwg/Grid2^ho-Jwg	Not Specified	MGI:3699324

Genotype
MGI:3699324

hm1

• Allelic Composition: Grid2^ho-Jwg/Grid2^ho-Jwg
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:10295 , J:14140 )

• mutants appear normal until 12-15 days after birth when they develop an ataxic gait (J:14140)

abnormal gait ( J:10295 , J:14140 )

• by 25 days of age, exhibit rapid alternating patting motions of all four limbs (J:14140)

• during locomotion, exhibit alternating stereotypic jerky flexions of the limbs, most pronounced in the hind limbs (J:14140)

reproductive system

abnormal sperm flagellum morphology ( J:10295 )

♂ • many sperm exhibit a reduplication of the flagellar structure and/or juxtaposition of distal portions of flagella to the head

abnormal sperm motility ( J:10295 )

♂ • sperm appear to move abnormally, with increased lateral head amplitude and decreased forward progression

reduced female fertility ( J:10295 )

♀ • although females produce litters, they are subfertile

reduced male fertility ( J:10295 , J:14140 )

♂ • males are capable of mating with females, despite the motor disorder, however fertility is severely reduced (J:10295)

♂ (J:14140)

impaired fertilization ( J:10295 )

♂ • spermatozoa show a marked reduction in the fertilization rate during in vitro fertilization

♂ • sperm are unable to penetrate the zona pellucida, however if a hole in the zona pellucida is made to allow the sperm access to the oocyte, sperm are capable of fertilizing the oocyte

impaired sperm penetration of zona pellucida ( J:10295 )

♂ • sperm are unable to penetrate the zona pellucida

nervous system

nervous system phenotype ( J:10295 )

N • exhibit no abnormalities in the brain, spinal cord, sciatic nerves, and dorsal root ganglia

cellular

abnormal sperm flagellum morphology ( J:10295 )

♂ • many sperm exhibit a reduplication of the flagellar structure and/or juxtaposition of distal portions of flagella to the head

abnormal sperm motility ( J:10295 )

♂ • sperm appear to move abnormally, with increased lateral head amplitude and decreased forward progression