Phenotypes associated with this allele

• Allele Symbol: Mgrn1^md-2J
• Allele Name: mahoganoid 2 Jackson
• Allele ID: MGI:1856072
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgrn1^md-2J/Mgrn1^md-2J	C3H/HeJ-Mgrn1^md-2J	MGI:3703518
hm2	Mgrn1^md-2J/Mgrn1^md-2J	involves: 129S1/SvImJ * C3H/HeJ	MGI:3704090

Genotype
MGI:3703518

hm1

• Allelic Composition: Mgrn1^md-2J/Mgrn1^md-2J
• Genetic Background: C3H/HeJ-Mgrn1^md-2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:119125 )

• have dark backs but some agouti hairs on their flanks

integument

abnormal coat/hair pigmentation ( J:119125 )

• have dark backs but some agouti hairs on their flanks

Genotype
MGI:3704090

hm2

• Allelic Composition: Mgrn1^md-2J/Mgrn1^md-2J
• Genetic Background: involves: 129S1/SvImJ * C3H/HeJ

mortality/aging

perinatal lethality, incomplete penetrance ( J:116645 )

• 60% of homozygote die before birth or during the first 3 weeks of life

postnatal lethality, incomplete penetrance ( J:116645 )

• 60% of homozygote die before birth or during the first 3 weeks of life

prenatal lethality, incomplete penetrance ( J:116645 )

• 60% of homozygote die before birth or during the first 3 weeks of life

growth/size/body

left pulmonary isomerism ( J:116645 )

• in some 12.5-18.5 d.p.c. homozygous embryos

lung situs inversus ( J:116645 )

• reversed lung situs in some 12.5-18.5 d.p.c. homozygous embryos

situs inversus ( J:116645 )

• found in a very small proportion (<1%) of adult homozygous mice

cardiovascular system

right aortic arch ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

abnormal left subclavian artery morphology ( J:116645 )

• retroesophageal left subclavian artery in 12.5-18.5 d.p.c. homozygous embryo

thin myocardium ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

abnormal coronary sinus morphology ( J:116645 )

• unroofed coronary sinus in 12.5-18.5 d.p.c. homozygous embryos

abnormal heart and great artery attachment ( J:116645 )

• malposition of the great artery of the heart in 12.5-18.5 d.p.c. homozygous embryo

double outlet right ventricle ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

atrial septal defect ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

dextrocardia ( J:116645 )

• in some 12.5-18.5 d.p.c. homozygous embryos

mesocardia ( J:116645 )

• n some 12.5-18.5 d.p.c. homozygous embryos

ventricular septal defect ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

pericardial effusion ( J:116645 )

• pericardial effusion in some 12.5-18.5 d.p.c. homozygous embryos

hemorrhage ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

congestive heart failure ( J:116645 )

• in some 12.5-18.5 d.p.c. homozygous embryos caused by congenital heart defects

respiratory system

left pulmonary isomerism ( J:116645 )

• in some 12.5-18.5 d.p.c. homozygous embryos

lung situs inversus ( J:116645 )

• reversed lung situs in some 12.5-18.5 d.p.c. homozygous embryos

pleural effusion ( J:116645 )

• pleural effusion in some 12.5-18.5 d.p.c. homozygous embryos

embryo

abnormal left-right axis patterning ( J:116645 )

• embryonic lethality resulted from congenital heart defects due to defective establishment and/or maintenance of the left-right axis

homeostasis/metabolism

pericardial effusion ( J:116645 )

• pericardial effusion in some 12.5-18.5 d.p.c. homozygous embryos

pleural effusion ( J:116645 )

• pleural effusion in some 12.5-18.5 d.p.c. homozygous embryos

muscle

thin myocardium ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos